Newcastle disease virus (NDV) is a virus that is of interest because it replicates (makes copies of itself) more quickly in human cancer cells than in most normal human cells and because it can kill these host cells (see Question 1).
NDV can be used to directly kill cancer cells, or it can be given as a cancervaccine. Cancer vaccines cause the body's natural immune system to seek out and destroy cancer cells (see Question 4).
The results of clinical trials (research studies with people)...
Revised text to state that the primary therapy for polycythemia vera (p. vera) includes intermittent, chronic phlebotomy to maintain the hematocrit below 45%, and this recommendation has been confirmed in a randomized, prospective trial, which demonstrated lower rates of cardiovascular death and major thrombosis using this hematocrit target (cited Marchioli et al. as reference 10).
Added Lavrenkov et al. as reference 33.
Added Jabbour et al. as reference 41.
Added Abelsson as reference 48.
Added text to state that patients with prefibrotic primary myelofibrosis may also have a higher tendency to bleed, which can be exacerbated by low-dose aspirin (cited Finazzi et al. as reference 4).
Added text to state that in an extrapolation of the data from trials of p. vera, low-dose aspirin to prevent vascular events has been suggested, but there are no data from clinical trials to address this issue (cited Finazzi as reference 15).
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WebMD Public Information from the National Cancer Institute
September 04, 2014
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