Caregivers usually define the onset of caregiving as the time of the patient's first cancer diagnosis; ideally, interventions for the caregiver should begin then. However, no validated model exists that can be applied to understanding the family caregiver experience, and few settings perform routine caregiver assessment—making the job of oncology practitioners more difficult, as they have no suitable framework for guiding their care decisions.
Generally speaking, interventions for the caregiver...
Revised text to state that the primary therapy for polycythemia vera (p. vera) includes intermittent, chronic phlebotomy to maintain the hematocrit below 45%, and this recommendation has been confirmed in a randomized, prospective trial, which demonstrated lower rates of cardiovascular death and major thrombosis using this hematocrit target (cited Marchioli et al. as reference 10).
Added Lavrenkov et al. as reference 33.
Added Jabbour et al. as reference 41.
Added Abelsson as reference 48.
Added text to state that patients with prefibrotic primary myelofibrosis may also have a higher tendency to bleed, which can be exacerbated by low-dose aspirin (cited Finazzi et al. as reference 4).
Added text to state that in an extrapolation of the data from trials of p. vera, low-dose aspirin to prevent vascular events has been suggested, but there are no data from clinical trials to address this issue (cited Finazzi as reference 15).
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September 04, 2014
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