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Chronic Myeloproliferative Disorders Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Chronic Myeloproliferative Disorders

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Chronic Myelogenous Leukemia

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See the PDQ summary about Chronic Myelogenous Leukemia Treatment for information.

Polycythemia Vera

The purpose of treatment for polycythemia vera is to reduce the number of extra blood cells. Treatment of polycythemia vera may include the following:

  • Phlebotomy.
  • Chemotherapy with or without phlebotomy.
  • Biologic therapy using interferon alfa or pegylated interferon alpha..
  • Low-dose aspirin.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with polycythemia vera. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Primary Myelofibrosis

Treatment of primary myelofibrosis in patients without symptoms is usually watchful waiting.

Patients with primary myelofibrosis may have symptoms of anemia. Anemia is usually treated with transfusion of red blood cells to relieve symptoms and improve quality of life. In addition, anemia may be treated with:

  • Erythropoietic growth factors.
  • Prednisone.
  • Danazol.
  • Thalidomide, lenalidomide, or pomalidomide, with or without prednisone.

Treatment of primary myelofibrosis in patients with other symptoms may include the following:

  • Targeted therapy with ruxolitinib.
  • Chemotherapy.
  • Donor stem cell transplant.
  • Thalidomide, lenalidomide, or pomalidomide.
  • Splenectomy.
  • Radiation therapy to the spleen, lymph nodes, or other areas outside the bone marrow where blood cells are forming.
  • Biologic therapy using interferon alfa or erythropoietic growth factors.
  • A clinical trial of other targeted therapy drugs.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with primary myelofibrosis. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

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