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Esophageal Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Esophageal Cancer

Table 4. Anatomic Stage/Prognostic Groupsa

Squamous Cell Carcinomab
StageTNMGradeTumor Locationc
HGD = high-grade dysplasia.
a Reprinted with permission from AJCC: Esophageal and esophagogastric junction. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 103-15.
b Or mixed histology, including a squamous component or not otherwise specified.
c Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.
0Tis (HGD)N0M01, XAny
IAT1N0M01, XAny
IBT1N0M02–3Any
T2–3N0M01, XLower, X
IIAT2–3N0M01, XUpper, middle
T2–3N0M02–3Lower, X
IIBT2–3N0M02–3Upper, middle
T1–2N1M0AnyAny
IIIAT1–2N2M0AnyAny
T3N1M0AnyAny
T4aN0M0AnyAny
IIIBT3N2M0AnyAny
IIICT4aN1–2M0AnyAny
T4bAnyM0AnyAny
AnyN3M0AnyAny
IVAnyAnyM1AnyAny
Adenocarcinoma
StageTNMGrade
0Tis (HGD)N0M01, X
IAT1N0M01–2, X
IBT1N0M03
T2N0M01–2, X
IIAT2N0M03
IIBT3N0M0Any
T1–2N1M0Any
IIIAT1–2N2M0Any
T3N1M0Any
T4aN0M0Any
IIIBT3N2M0Any
IIICT4aN1–2M0Any
T4bAnyM0Any
AnyN3M0Any
IVAnyAnyM1Any

The current staging system for esophageal cancer is based largely on retrospective data from the Japanese Committee for Registration of Esophageal Carcinoma. It is most applicable to patients with squamous cell carcinomas of the upper third and middle third of the esophagus, as opposed to the increasingly common distal esophageal and gastroesophageal junction adenocarcinomas.[2] In particular, the classification of involved abdominal lymph nodes as M1 disease has been criticized. The presence of positive abdominal lymph nodes does not appear to carry as grave a prognosis as metastases to distant organs.[3] Patients with regional and/or celiac axis lymphadenopathy should not necessarily be considered to have unresectable disease caused by metastases. Complete resection of the primary tumor and appropriate lymphadenectomy should be attempted when possible.

References:

  1. Esophagus and esophagogastric junction. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 103-11.
  2. Iizuka T, Isono K, Kakegawa T, et al.: Parameters linked to ten-year survival in Japan of resected esophageal carcinoma. Japanese Committee for Registration of Esophageal Carcinoma Cases. Chest 96 (5): 1005-11, 1989.
  3. Korst RJ, Rusch VW, Venkatraman E, et al.: Proposed revision of the staging classification for esophageal cancer. J Thorac Cardiovasc Surg 115 (3): 660-69; discussion 669-70, 1998.

This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

WebMD Public Information from the National Cancer Institute

Last Updated: September 04, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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