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    Esophageal Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Esophageal Cancer

    Table 4. Anatomic Stage/Prognostic Groupsa

    Squamous Cell Carcinoma b
    Stage T N M Grade Tumor Locationc
    HGD = high-grade dysplasia.
    a Reprinted with permission from AJCC: Esophageal and esophagogastric junction. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 103-15.
    b Or mixed histology, including a squamous component or not otherwise specified.
    c Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumor in the esophagus.
    0 Tis (HGD) N0 M0 1, X Any
    IA T1 N0 M0 1, X Any
    IB T1 N0 M0 2-3 Any
    T2-3 N0 M0 1, X Lower, X
    IIA T2-3 N0 M0 1, X Upper, middle
    T2-3 N0 M0 2-3 Lower, X
    IIB T2-3 N0 M0 2-3 Upper, middle
    T1-2 N1 M0 Any Any
    IIIA T1-2 N2 M0 Any Any
    T3 N1 M0 Any Any
    T4a N0 M0 Any Any
    IIIB T3 N2 M0 Any Any
    IIIC T4a N1-2 M0 Any Any
    T4b Any M0 Any Any
    Any N3 M0 Any Any
    IV Any Any M1 Any Any
    Adenocarcinoma
    Stage T N M Grade
    0 Tis (HGD) N0 M0 1, X
    IA T1 N0 M0 1-2, X
    IB T1 N0 M0 3
    T2 N0 M0 1-2, X
    IIA T2 N0 M0 3
    IIB T3 N0 M0 Any
    T1-2 N1 M0 Any
    IIIA T1-2 N2 M0 Any
    T3 N1 M0 Any
    T4a N0 M0 Any
    IIIB T3 N2 M0 Any
    IIIC T4a N1-2 M0 Any
    T4b Any M0 Any
    Any N3 M0 Any
    IV Any Any M1 Any

    The current staging system for esophageal cancer is based largely on retrospective data from the Japanese Committee for Registration of Esophageal Carcinoma. It is most applicable to patients with squamous cell carcinomas of the upper third and middle third of the esophagus, as opposed to the increasingly common distal esophageal and gastroesophageal junction adenocarcinomas.[2] In particular, the classification of involved abdominal lymph nodes as M1 disease has been criticized. The presence of positive abdominal lymph nodes does not appear to carry as grave a prognosis as metastases to distant organs.[3] Patients with regional and/or celiac axis lymphadenopathy should not necessarily be considered to have unresectable disease caused by metastases. Complete resection of the primary tumor and appropriate lymphadenectomy should be attempted when possible.

    References:

    1. Esophagus and esophagogastric junction. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 103-11.
    2. Iizuka T, Isono K, Kakegawa T, et al.: Parameters linked to ten-year survival in Japan of resected esophageal carcinoma. Japanese Committee for Registration of Esophageal Carcinoma Cases. Chest 96 (5): 1005-11, 1989.
    3. Korst RJ, Rusch VW, Venkatraman E, et al.: Proposed revision of the staging classification for esophageal cancer. J Thorac Cardiovasc Surg 115 (3): 660-69; discussion 669-70, 1998.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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