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    Extragonadal Germ Cell Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Cellular Classification of Extragonadal Germ Cell Tumors

    continued...

    28% of nonseminomas

    5-year PFS rate of 75%

    5-year survival rate of 80%

    Seminoma

    • Any primary site

      and

    • Nonpulmonary visceral metastases

      and

    • Normal AFP, any hCG, any LDH

    10% of seminomas

    5-year PFS rate of 67%

    5-year survival rate of 72%

    Poor Prognosis

    Nonseminoma

    • Mediastinal primary

      or

    • Nonpulmonary visceral metastases

      or

    • Poor markers - any of:
      • AFP greater than 10,000 ng/mL

        or

      • hCG greater than 50,000 iu/L (1,000 ng/mL)

        or

      • LDH greater than 10 × upper limit of normal

    16% of nonseminomas

    5-year PFS rate of 41%

    5-year survival rate of 48%

    Seminoma

    No patients are classified as poor prognosis.

    References:

    1. Mayordomo JI, Paz-Ares L, Rivera F, et al.: Ovarian and extragonadal malignant germ-cell tumors in females: a single-institution experience with 43 patients. Ann Oncol 5 (3): 225-31, 1994.
    2. Greco FA, Vaughn WK, Hainsworth JD: Advanced poorly differentiated carcinoma of unknown primary site: recognition of a treatable syndrome. Ann Intern Med 104 (4): 547-53, 1986.
    3. Hainsworth JD, Greco FA: Extragonadal germ cell tumors and unrecognized germ cell tumors. Semin Oncol 19 (2): 119-27, 1992.
    4. International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group. J Clin Oncol 15 (2): 594-603, 1997.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: 8/, 015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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