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Extrahepatic Bile Duct Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Stages of Extrahepatic Bile Duct Cancer

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Stage IV

Stage IV is divided into stages IVA and IVB.

  • Stage IVA: The tumor may have spread to nearby lymph nodes and has spread to one or more of the following:
    • the main part of the portal vein (a vessel that carries blood away from the liver) or both branches of the portal vein;
    • the hepatic artery (a vessel that carries blood to the liver);
    • the right and left hepatic ducts;
    • the right hepatic duct and the left branch of the hepatic artery or of the portal vein;
    • the left hepatic duct and the right branch of the hepatic artery or of the portal vein.
  • Stage IVB: The tumor has spread to other parts of the body, such as the liver.

The following stages are used for distal extrahepatic bile duct cancer:

Stage 0 (Carcinoma in Situ)

In stage 0, abnormal cells are found in the innermost layer of tissue lining the distal bile duct. These abnormal cells may become cancer and spread into nearby normal tissue. Stage 0 is also called carcinoma in situ.

Stage I

In stage I, cancer has formed. Stage I is divided into stages IA and IB.

  • Stage IA: Cancer is found in the distal bile duct only.
  • Stage IB: Cancer has spread all the way through the wall of the distal bile duct.

Stage II

Stage II is divided into stages IIA and IIB.

  • Stage IIA: Cancer has spread from the distal bile duct to the gallbladder, pancreas, small intestine, or other nearby organs.
  • Stage IIB: Cancer has spread from the distal bile duct to nearby lymph nodes. Cancer may have spread through the wall of the distal bile duct or to the gallbladder, pancreas, small intestine, or other nearby organs.

Stage III

In stage III, cancer has spread to the large vessels that carry blood to the organs in the abdomen. Cancer may have spread to nearby lymph nodes.

Stage IV

In stage IV, cancer has spread to other parts of the body, such as the liver or lungs.

Extrahepatic bile duct cancer can also be grouped according to how the cancer may be treated. There are two treatment groups:

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