Almost all hypopharyngeal cancers are epithelial in origin, predominantly squamous cell (i.e., epidermoid) carcinomas (SCCs), and may be preceded by various precancerous lesions.[1,2] Rare types of hypopharyngeal carcinomas include the following:
Basaloid squamoid carcinomas.
Spindle-cell (i.e., sarcomatoid) carcinomas.
Nasopharyngeal-type undifferentiated carcinomas (i.e., lymphoepitheliomas).
Carcinomas of the minor salivary glands.