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Retinoblastoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Cellular Classification

Retinoblastoma is composed mainly of undifferentiated anaplastic cells that arise from the retina. Histology shows similarity to neuroblastoma and medulloblastoma, including aggregation around blood vessels, necrosis, calcification, and Flexner-Wintersteiner rosettes. Retinoblastomas are characterized by marked cell proliferation as evidenced by high mitosis counts and extremely high MIB-1 labeling indices.[1]

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Description of the Evidence

Background Incidence and mortality An estimated 41,380 new cases of oral cancer will be diagnosed in the United States in 2013, and an estimated 7,890 people will die of the disease.[1] This form of cancer accounts for about 3% of cancers in men.[1] The overall annual incidence in the United States is about 10.8 per 100,000 men and women; the median age at diagnosis of oral cavity or pharyngeal cancer was 62 years from 2005 to 2009.[2] Incidence has been falling in men since 1975 and...

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  1. Schwimer CJ, Prayson RA: Clinicopathologic study of retinoblastoma including MIB-1, p53, and CD99 immunohistochemistry. Ann Diagn Pathol 5 (3): 148-54, 2001.
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WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
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