Treatment of fatigue depends on the symptoms and whether the cause of fatigue is known. When the cause of fatigue is not known, treatment is usually given to relieve symptoms and teach the patient ways to cope with fatigue.
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with childhood liver cancer. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
Transfusions work well to treat anemia. Possible side effects of transfusions include an allergic reaction, infection, graft-versus-host disease, immune system changes, and too much iron in the blood.
Drugs that cause the bone marrow to make more red blood cells may be used to treat anemia-related fatigue in patients receiving chemotherapy. Epoetin alfa and darbepoetin alfa are two of these drugs. This type of drug may shorten survival time, increase the risk of serious heart problems, and cause some tumors to grow faster or recur. The Food and Drug Administration (FDA) has not approved these drugs for the treatment of fatigue. Discuss the risks and benefits of these drugs with your doctor.
Treatment of pain
If pain is making fatigue worse, the patient's pain medicine may be changed or the dose may be increased. If too much pain medicine is making fatigue worse, the patient's pain medicine may be changed or the dose may be decreased.
Treatment of depression
Fatigue in patients who have depression may be treated with antidepressant drugs. Psychostimulant drugs may help some patients have more energy and a better mood, and help them think and concentrate. The use of psychostimulants for treating fatigue is still being studied. The FDA has not approved psychostimulants for the treatment of fatigue.
Psychostimulants have side effects, especially with long-term use. Different psychostimulants have different side effects. Patients who have heart problems or who take anticancer drugs that affect the heart may have serious side effects from psychostimulants. These drugs have warnings on the label about their risks. Talk to your doctor about the effects these drugs may have and use them only under a doctor's care. Some of the possible side effects include the following:
Paranoia (feelings of fear and distrust of other people).
Serious heart problems.
The doctor may prescribe low doses of a psychostimulant to be used for a short time in patients with advanced cancer who have severe fatigue. Talk to your doctor about the risks and benefits of these drugs.