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Fatigue (PDQ®): Supportive care - Patient Information [NCI] - Treatments for Fatigue

Fatigue in cancer patients is often treated by relieving related conditions such as anemia and depression.

Treatment of fatigue depends on the symptoms and whether the cause of fatigue is known. When the cause of fatigue is not known, treatment is usually given to relieve symptoms and teach the patient ways to cope with fatigue.

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About This PDQ Summary

Purpose of This Summary This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of adult soft tissue sarcoma. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions. Reviewers and Updates This summary is reviewed regularly and updated as necessary by the PDQ Adult Treatment...

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Treatment of anemia

Treating anemia may help decrease fatigue. When known, the cause of the anemia is treated. When the cause is not known, treatment for anemia is supportive care and may include the following:

  • Change in diet

    Eating more foods rich in iron and vitamins may be combined with other treatments for anemia.

  • Transfusions of red blood cells

    Transfusions work well to treat anemia. Possible side effects of transfusions include an allergic reaction, infection, graft-versus-host disease, immune system changes, and too much iron in the blood.

  • Medicine

    Drugs that cause the bone marrow to make more red blood cells may be used to treat anemia-related fatigue in patients receiving chemotherapy. Epoetin alfa and darbepoetin alfa are two of these drugs. This type of drug may shorten survival time, increase the risk of serious heart problems, and cause some tumors to grow faster or recur. The Food and Drug Administration (FDA) has not approved these drugs for the treatment of fatigue. Discuss the risks and benefits of these drugs with your doctor.

Treatment of pain

If pain is making fatigue worse, the patient's pain medicine may be changed or the dose may be increased. If too much pain medicine is making fatigue worse, the patient's pain medicine may be changed or the dose may be decreased.

Treatment of depression

Fatigue in patients who have depression may be treated with antidepressant drugs. Psychostimulant drugs may help some patients have more energy and a better mood, and help them think and concentrate. The use of psychostimulants for treating fatigue is still being studied. The FDA has not approved psychostimulants for the treatment of fatigue.

Psychostimulants have side effects, especially with long-term use. Different psychostimulants have different side effects. Patients who have heart problems or who take anticancer drugs that affect the heart may have serious side effects from psychostimulants. These drugs have warnings on the label about their risks. Talk to your doctor about the effects these drugs may have and use them only under a doctor's care. Some of the possible side effects include the following:

The doctor may prescribe low doses of a psychostimulant to be used for a short time in patients with advanced cancer who have severe fatigue. Talk to your doctor about the risks and benefits of these drugs.

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WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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