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Gallbladder Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Gallbladder Cancer

Definitions of TNM

The American Joint Committee on Cancer has designated staging by the TNM classification to define gallbladder cancer.[1]

Table 1. Primary Tumor (T)a

a Reprinted with permission from AJCC: Gallbladder. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 211-7.
TXPrimary tumor cannot be assessed.
T0No evidence of primary tumor.
TisCarcinomain situ.
T1Tumor invades lamina propria or muscular layer.
T1aTumor invades lamina propria.
T1bTumor invades muscular layer.
T2Tumor invades perimuscular connective tissue; no extension beyond serosa or into liver.
T3Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts.
T4Tumor invades main portal vein or hepatic artery or invades at least two extrahepatic organs or structures.

Table 2. Regional Lymph Nodes (N)a

a Reprinted with permission from AJCC: Gallbladder. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 211-7.
NXRegional lymph nodes cannot be assessed.
N0No regional lymph node metastasis.
N1Metastases to nodes along the cystic duct, common bile duct, hepatic artery, and/or portal vein.
N2Metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes.

Table 3. Distant Metastasis (M)a

a Reprinted with permission from AJCC: Gallbladder. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 211-7.
M0No distant metastasis.
M1Distant metastasis.

Table 4. Anatomic Stage/Prognostic Groups

StageTNM
a Reprinted with permission from AJCC: Gallbladder. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 211-7.
0TisN0M0
IT1N0M0
IIT2N0M0
IIIAT3N0M0
IIIBT1–3N1M0
IVAT4N0–1M0
IVBAny TN2M0
Any TAny NM1
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