Radiation enteritis is inflammation of the intestine caused by radiation therapy.
Radiation enteritis is a condition in which the lining of the intestine becomes swollen and inflamed during or after radiation therapy to the abdomen, pelvis, or rectum. The small and large intestine are very sensitive to radiation. The larger the dose of radiation, the more damage may be done to normal tissue. Most tumors in the abdomen and pelvis need large doses of radiation. Almost all patients receiving radiation to the abdomen, pelvis, or rectum will have enteritis.
Although they comprise fewer than 1% of all gastrointestinal (GI) tumors, gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the GI tract. It has been estimated that there are 3,300 to 6,000 new GIST cases per year in the United States. A study based on Surveillance, Epidemiology and End Results (SEER) registry data found that the age-adjusted yearly incidence of GIST in the United States was 6.8 per million from 1992 to 2000. However, the...
Radiation therapy to kill cancer cells in the abdomen and pelvis affects normal cells in the lining of the intestines. Radiation therapy stops the growth of cancer cells and other fast-growing cells. Since normal cells in the lining of the intestines grow quickly, radiation treatment to that area can stop those cells from growing. This makes it hard for tissue to repair itself. As cells die and are not replaced, gastrointestinal problems occur over the next few days and weeks.
Doctors are studying whether the order that radiation therapy, chemotherapy, and surgery are given affects how severe the enteritis will be.
Symptoms may begin during radiation therapy or months to years later.
Radiation enteritis may be acute or chronic:
Acute radiation enteritis occurs during radiation therapy and may last up to 8 to 12 weeks after treatment stops.
Chronic radiation enteritis may appear months to years after radiation therapy ends, or it may begin as acute enteritis and keep coming back.
The total dose of radiation and other factors affect the risk of radiation enteritis.
Only 5% to 15% of patients treated with radiation to the abdomen will have chronic problems. The amount of time the enteritis lasts and how severe it is depend on the following:
The total dose of radiation received.
The amount of normal intestine treated.
The tumor size and how much it has spread.
If chemotherapy was given at the same time as the radiation therapy.
If radiation implants were used.
If the patient has high blood pressure, diabetes, pelvic inflammatory disease, or poor nutrition.
If the patient has had surgery to the abdomen or pelvis.