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Genetics of Colorectal Cancer (PDQ®): Genetics - Health Professional Information [NCI] - About This PDQ Summary

Purpose of This Summary

This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the genetics of colorectal cancer. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.

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General Information About Langerhans Cell Histiocytosis (LCH)

Langerhans cell histiocytosis is a type of cancer that can damage tissue or cause lesions to form in one or more places in the body. Langerhans cell histiocytosis (LCH) is a rare cancer that begins in LCH cells (a type of dendritic cell which fights infection). Sometimes there are mutations (changes) in LCH cells as they form. These include mutations of the BRAFgene. These changes may make the LCH cells grow and multiply quickly. This causes LCH cells to build up in certain parts of the body,...

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Reviewers and Updates

This summary is reviewed regularly and updated as necessary by the PDQ Cancer Genetics Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH).

Board members review recently published articles each month to determine whether an article should:

  • be discussed at a meeting,
  • be cited with text, or
  • replace or update an existing article that is already cited.

Changes to the summaries are made through a consensus process in which Board members evaluate the strength of the evidence in the published articles and determine how the article should be included in the summary.

The lead reviewers for Genetics of Colorectal Cancer are:

  • Kathleen A. Calzone, PhD, RN, APNG, FAAN (National Cancer Institute)
  • Donald W. Hadley, MS, CGC (National Human Genome Research Institute)
  • Jennifer Lynn Hay, PhD (Memorial Sloan-Kettering Cancer Center)
  • Scott Kuwada, MD, AGAF, FACP (University of Hawaii)
  • Patrick M. Lynch, MD, JD (University of Texas, M.D. Anderson Cancer Center)
  • Suzanne M. O'Neill, MS, PhD, CGC (Northwestern University)
  • Susan K. Peterson, PhD, MPH (University of Texas, M.D. Anderson Cancer Center)
  • Miguel A. Rodriguez-Bigas, MD (University of Texas, M.D. Anderson Cancer Center)
  • Danielle Kim Turgeon, MD (University of Michigan Comprehensive Cancer Center)
  • Susan T. Vadaparampil, PhD, MPH (H. Lee Moffitt Cancer Center & Research Institute)
  • Catharine Wang, PhD, MSc (Boston University School of Public Health)
  • Kevin Zbuk, MD, FRCPC (Margaret and Charles Juravinski Cancer Centre)

Any comments or questions about the summary content should be submitted to through the Web site's Contact Form. Do not contact the individual Board Members with questions or comments about the summaries. Board members will not respond to individual inquiries.

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