Skip to content

    Cancer Health Center

    Font Size
    A
    A
    A

    Genetics of Colorectal Cancer (PDQ®): Genetics - Health Professional Information [NCI] - Colon Cancer Genes

    Major Genes

    Major genes are defined as those that are necessary and sufficient for disease causation, with important mutations (e.g., nonsense, missense, frameshift) of the gene as causal mechanisms. Major genes are typically considered those that are involved in single-gene disorders, and the diseases caused by major genes are often relatively rare. Most pathogenic mutations in major genes lead to a very high risk of disease, and environmental contributions are often difficult to recognize.[1] Historically, most major colon cancer susceptibility genes have been identified by linkage analysis using high-risk families; thus, these criteria were fulfilled by definition, as a consequence of the study design.

    The functions of the major colon cancer genes have been reasonably well characterized over the past decade. Three proposed classes of colon cancer genes are tumor suppressor genes, oncogenes, and DNA repair genes.[2] Tumor suppressor genes constitute the most important class of genes responsible for hereditary cancer syndromes and represent the class of genes responsible for both familial adenomatous polyposis (FAP) and juvenile polyposis syndrome (JPS), among others. Germline mutations of oncogenes are not an important cause of inherited susceptibility to colorectal cancer (CRC), even though somatic mutations in oncogenes are ubiquitous in virtually all forms of gastrointestinal cancers. Stability genes, especially the mismatch repair (MMR) genes responsible for Lynch syndrome (LS) (also called hereditary nonpolyposis colorectal cancer [HNPCC]), account for a substantial fraction of hereditary CRC, as noted below. (Refer to the Lynch syndrome [LS] section in the Major Genetic Syndromes section of this summary for more information). MYH is another important example of a stability gene that confers risk of CRC based on defective base excision repair. Table 2 summarizes the genes that confer a substantial risk of CRC, with their corresponding diseases.

    Table 2. Genes Associated with a High Susceptibility of Colorectal Cancer

    Gene Syndrome Hereditary Pattern Predominant Cancer
    FAP = familial adenomatous polyposis; JPS = juvenile polyposis syndrome; LS = Lynch syndrome; OMIM = Online Mendelian Inheritance in Man database; PJS = Peutz-Jeghers syndrome.
    Tumor suppressor genes
    APC(OMIM) FAP Dominant Colon, intestine, etc.
    TP53(p53) (OMIM) Li-Fraumeni Dominant Multiple (including colon)
    STK11(LKB1) (OMIM) PJS Dominant Multiple (including intestine)
    PTEN(OMIM) Cowden Dominant Multiple (including intestine)
    BMPR1A(OMIM) JPS Dominant Gastrointestinal
    SMAD4(MADH/DPC4) (OMIM) JPS Dominant Gastrointestinal
    Repair/stability genes
    MLH1(OMIM),MSH2(OMIM),MSH6(OMIM),PMS2 (OMIM) LS Dominant Multiple (including colon, uterus, and others)
    EPCAM (TACSTD1) (OMIM) LS Dominant Multiple (including colon, uterus, and others)
    MYH(MUTYH) (OMIM) MYH-associated polyposis Recessive Colon
    POLD1(OMIM),POLE(OMIM) Oligopolyposis Dominant Colon, endometrial
    1 | 2 | 3 | 4 | 5 | 6 | 7 | 8
    1 | 2 | 3 | 4 | 5 | 6 | 7 | 8
    Next Article:

    Today on WebMD

    Colorectal cancer cells
    New! I AM Not Cancer Facebook Group
    Lung cancer xray
    See it in pictures, plus read the facts.
     
    sauteed cherry tomatoes
    Fight cancer one plate at a time.
    Ovarian cancer illustration
    Real Cancer Perspectives
     
    Jennifer Goodman Linn self-portrait
    Blog
    what is your cancer risk
    HEALTH CHECK
     
    colorectal cancer treatment advances
    Video
    breast cancer overview slideshow
    SLIDESHOW
     
    prostate cancer overview
    SLIDESHOW
    lung cancer overview slideshow
    SLIDESHOW
     
    ovarian cancer overview slideshow
    SLIDESHOW
    Actor Michael Douglas
    Article