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Genetics of Colorectal Cancer (PDQ®): Genetics - Health Professional Information [NCI] - Colon Cancer Genes

Table 3. Colorectal Cancer Susceptibility Loci Identified Through Genome-Wide Association Studies

ChromosomeLogarithm of the Odds (LOD) Score/Odds Ratio (OR)P ValueSingle Nucleotide Polymorphism (SNP)Marker
ORhet = odds ratio among heterozygotes; ORhom = odds ratio among homozygotes.
a Identified in a breast/colon cohort.
3q29LOD = 2.61[27].0003 D3S240
4q31.3LOD = 2.13[27].0009 D4S2999
7q31.31LOD = 3.08[27].00008 D7S643
8q23.3Combined OR = 1.29[24]1.1 × 10-10rs11986063 
8q23.3ORallelic = 1.25, ORhet = 1.27, ORhom = 1.43[22]3.3 × 10-18rs16892766 
Combined OR = 1.32[24]1.1 × 10-10
8q24ORallelic = 1.24, ORhet = 1.35, ORhom = 1.57[22]7.0 × 10-11rs6983267 
Combined OR = 0.83[24]2.1 × 10-14
8q24OR = 1.19[23]8.6 × 10-26rs7014346 
Combined OR = 1.21[24]3.0 × 10-13
8q24Combined OR = 1.17[24]1.2 × 10-10rs7837328 
8q24Combined OR = 1.14[24]1.5 × 10-7rs10808555 
10p14ORallelic = 0.89, ORhet = 0.87, ORhom = 0.80[22]2.5 × 10-13rs10795668 
Combined OR = 0.91[24]3.1 × 10-4
11q23OR = 1.11[23]5.8 × 10-10rs3802842 
Combined OR = 1.21[24]5.2 × 10-13
14q22.2Combined OR = 1.11[24]8.1 × 10-10rs4444235 
15q13ORallelic = 1.23, ORhet = 1.17, ORhom = 1.70[22]4.7 × 10-7rs4779584 
Combined OR = 1.19[24]1.7 × 10-8
16q22.1Combined OR = 0.91[24]1.2 × 10-8rs9929218 
17p13.3aNot available[26].0364 D17S1308
18q21ORallelic = 0.85, ORhet = 0.84, ORhom = 0.73[22]1.7 × 10-6rs4939827 
OR = 1.20[23]7.8 × 10-28
Combined OR = 0.85[24]2.2 × 10-11
19q13.1Combined OR = 0.89[24]2.2 × 10-7rs7259371 
19q13.1Combined OR = 0.87[24]4.6 × 10-9rs10411210 
20p12.3Combined OR = 1.12[24]2.0 × 10-10rs355527 
20p12.3Combined OR = 1.12[24]2.1 10-10rs961253 
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