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Cancer Health Center

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Genetics of Colorectal Cancer (PDQ®): Genetics - Health Professional Information [NCI] - Colon Cancer Genes

Table 3. Colorectal Cancer Susceptibility Loci Identified Through Genome-Wide Association Studies

Chromosome Logarithm of the Odds (LOD) Score/Odds Ratio (OR) P Value Single Nucleotide Polymorphism (SNP) Marker
ORhet = odds ratio among heterozygotes; ORhom = odds ratio among homozygotes.
a Identified in a breast/colon cohort.
3q29 LOD = 2.61[27] .0003 D3S240
4q31.3 LOD = 2.13[27] .0009 D4S2999
7q31.31 LOD = 3.08[27] .00008 D7S643
8q23.3 Combined OR = 1.29[24] 1.1 × 10-10 rs11986063
8q23.3 ORallelic = 1.25, ORhet = 1.27, ORhom = 1.43[22] 3.3 × 10-18 rs16892766
Combined OR = 1.32[24] 1.1 × 10-10
8q24 ORallelic = 1.24, ORhet = 1.35, ORhom = 1.57[22] 7.0 × 10-11 rs6983267
Combined OR = 0.83[24] 2.1 × 10-14
8q24 OR = 1.19[23] 8.6 × 10-26 rs7014346
Combined OR = 1.21[24] 3.0 × 10-13
8q24 Combined OR = 1.17[24] 1.2 × 10-10 rs7837328
8q24 Combined OR = 1.14[24] 1.5 × 10-7 rs10808555
10p14 ORallelic = 0.89, ORhet = 0.87, ORhom = 0.80[22] 2.5 × 10-13 rs10795668
Combined OR = 0.91[24] 3.1 × 10-4
11q23 OR = 1.11[23] 5.8 × 10-10 rs3802842
Combined OR = 1.21[24] 5.2 × 10-13
14q22.2 Combined OR = 1.11[24] 8.1 × 10-10 rs4444235
15q13 ORallelic = 1.23, ORhet = 1.17, ORhom = 1.70[22] 4.7 × 10-7 rs4779584
Combined OR = 1.19[24] 1.7 × 10-8
16q22.1 Combined OR = 0.91[24] 1.2 × 10-8 rs9929218
17p13.3a Not available[26] .0364 D17S1308
18q21 ORallelic = 0.85, ORhet = 0.84, ORhom = 0.73[22] 1.7 × 10-6 rs4939827
OR = 1.20[23] 7.8 × 10-28
Combined OR = 0.85[24] 2.2 × 10-11
19q13.1 Combined OR = 0.89[24] 2.2 × 10-7 rs7259371
19q13.1 Combined OR = 0.87[24] 4.6 × 10-9 rs10411210
20p12.3 Combined OR = 1.12[24] 2.0 × 10-10 rs355527
20p12.3 Combined OR = 1.12[24] 2.1 10-10 rs961253
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8
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