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Treatment Option Overview


    Intermediate Prognosis


    • Testis/retroperitoneal primary, and
    • No nonpulmonary visceral metastases, and
    • Intermediate markers–any of:
      • AFP 1,000 ng/mL or more and 10,000 ng/mL or less, or
      • hCG 5,000 IU/L or more and 50,000 IU/L or less, or
      • LDH 1.5 or more × N* and less than 10 × N*

      13%–28% of nonseminomas

      5-year PFS is 75%; 5-year survival is 80%–83%

      *N indicates the upper limit of normal for the LDH assay.


    • Any primary site, and
    • Nonpulmonary visceral metastases, and
    • Normal AFP, any hCG, any LDH

      10% of seminomas

      5-year PFS is 67%; 5-year survival is 72%

    Poor Prognosis


    • Mediastinal primary, or
    • Nonpulmonary visceral metastases, or
    • For markers–any of:
      • AFP more than 10,000 ng/mL, or
      • hCG more than 50,000 IU/mL (10,000 ng/mL), or
      • LDH more than 10 × the upper limit of normal

      16%–26% of nonseminomas

      5-year PFS is 41%; 5-year survival is 71%


    • No patients are classified as poor prognosis.


    1. International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group. J Clin Oncol 15 (2): 594-603, 1997.
    2. van Dijk MR, Steyerberg EW, Habbema JD: Survival of non-seminomatous germ cell cancer patients according to the IGCC classification: An update based on meta-analysis. Eur J Cancer 42 (7): 820-6, 2006.

    WebMD Public Information from the National Cancer Institute

    Last Updated: February 25, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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