AFP 1,000 ng/mL or more and 10,000 ng/mL or less, or
hCG 5,000 IU/L or more and 50,000 IU/L or less, or
LDH 1.5 or more × N* and less than 10 × N*
13%–28% of nonseminomas
5-year PFS is 75%; 5-year survival is 80%–83%
*N indicates the upper limit of normal for the LDH assay.
Any primary site, and
Nonpulmonary visceral metastases, and
Normal AFP, any hCG, any LDH
10% of seminomas
5-year PFS is 67%; 5-year survival is 72%
Mediastinal primary, or
Nonpulmonary visceral metastases, or
For markers–any of:
AFP more than 10,000 ng/mL, or
hCG more than 50,000 IU/mL (10,000 ng/mL), or
LDH more than 10 × the upper limit of normal
16%–26% of nonseminomas
5-year PFS is 41%; 5-year survival is 71%
No patients are classified as poor prognosis.
International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group. J Clin Oncol 15 (2): 594-603, 1997.
van Dijk MR, Steyerberg EW, Habbema JD: Survival of non-seminomatous germ cell cancer patients according to the IGCC classification: An update based on meta-analysis. Eur J Cancer 42 (7): 820-6, 2006.
WebMD Public Information from the National Cancer Institute
February 25, 2014
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