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Cancer Health Center

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Gonzalez Regimen (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - History


Doubts exist about the effectiveness of oral administration of pancreatic enzymes because pancreatic enzymes were not thought to be transported intact from the gut to the bloodstream. Evidence now suggests that intact digestive enzymes can be absorbed and resecreted by the pancreas, in a manner similar to the liver recycling of bile salts and hormones.[10,11,12]


  1. Kelley WD: One Answer to Cancer. Mount Pearl, Canada: Cancer Coalition for Alternative Therapies, Inc. 1999. Also available online. Last accessed February 4, 2014.
  2. Gonzalez NJ, Isaacs LL: Evaluation of pancreatic proteolytic enzyme treatment of adenocarcinoma of the pancreas, with nutrition and detoxification support. Nutr Cancer 33 (2): 117-24, 1999.
  3. Gonzalez N: Dr. Nicholas Gonzalez on nutritional cancer therapy: a Moneychanger interview. The Moneychanger July 1995. Also available online. Last accessed February 4, 2014.
  4. Gonzalez NJ: Pancreatic cancer, proteolytic enzyme therapy and detoxification [excerpts]. Clinical Pearls News November 1999. Also available online. Last accessed February 4, 2014.
  5. Kelley WD, Rohe F: Cancer: Curing the Incurable without Surgery, Chemotherapy, or Radiation. Bonita, Calif: New World Promotions, 2005.
  6. Beard J: The Enzyme Treatment of Cancer and its Scientific Basis. London: Chatto & Windus, 1911.
  7. Gerson M: The cure of advanced cancer by diet therapy: a summary of 30 years of clinical experimentation. Physiol Chem Phys 10 (5): 449-64, 1978.
  8. Krebs ET Jr, Krebs ET Sr, Beard HH: The unitarian or trophoblastic thesis of cancer. Med Rec 163 (7): 149-74, 1950.
  9. Cohen LA, Aliaga C, Pittman B, et al.: Oral enzyme therapy and experimental rat mammary tumor metastasis. Life Sci 65 (24): 2603-14, 1999.
  10. Leibow C, Rothman SS: Enteropancreatic circulation of digestive enzymes. Science 189 (4201): 472-4, 1975.
  11. Rothman S, Liebow C, Isenman L: Conservation of digestive enzymes. Physiol Rev 82 (1): 1-18, 2002.
  12. Isenman L, Liebow C, Rothman S: Transport of proteins across membranes--a paradigm in transition. Biochim Biophys Acta 1241 (3): 341-70, 1995.

This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

WebMD Public Information from the National Cancer Institute

Last Updated: 8/, 015
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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