Cancer of the hypopharynx is uncommon; approximately 2,500 new cases are diagnosed in the United States each year. The peak incidence of this cancer occurs in males and females aged 50 to 60 years. Excessive alcohol and tobacco use are the primary risk factors for hypopharyngeal cancer.[3,4] In the United States, hypopharyngeal cancers are more common in men than in women. In Europe and Asia, high incidences of pharyngeal cancers, namely, oropharyngeal and hypopharyngeal, have been found...
Added text to state that hairy cell leukemia is an indolent, low-grade, B-cell lymphoma usually characterized by circulating B-cells with cytoplasmic projections, splenomegaly, absent lymphadenopathy, pancytopenia, and monocytopenia.
Added text to state that in addition to the B-cell antigens CD19, CD20, and CD22, the cells coexpress CD11c, CD25, and CD103. Also added that the BRAF-V600E mutation is a hairy cell leukemia–defining genetic lesion that can be used diagnostically (cited Tiacci et al. and Naik et al. as references 1 and 2, respectively).
Relapsed or Refractory Hairy Cell Leukemia
Added Gerrie et al., Ranvandi et al., and Else et al. as references 11, 16, and 17, respectively.
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WebMD Public Information from the National Cancer Institute
September 04, 2014
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