The hairy cell leukemia variant has a distinctive phenotype and typically presents with leukocytosis instead of leukopenia. Patients with this variant have poorer responses to initial cladribine, shorter durations of response, and typically do not respond again to purine analogues after relapse. Combinations of rituximab and purine analogues are under evaluation and further studies are required to define optimal therapies.[18,19]
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Golomb HM, Vardiman JW: Response to splenectomy in 65 patients with hairy cell leukemia: an evaluation of spleenweight and bone marrow involvement. Blood 61 (2): 349-52, 1983.
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Matutes E, Wotherspoon A, Catovsky D: The variant form of hairy-cell leukaemia. Best Pract Res Clin Haematol 16 (1): 41-56, 2003.
Else M, Osuji N, Forconi F, et al.: The role of rituximab in combination with pentostatin or cladribine for the treatment of recurrent/refractory hairy cell leukemia. Cancer 110 (10): 2240-7, 2007.
Arons E, Suntum T, Stetler-Stevenson M, et al.: VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapy. Blood 114 (21): 4687-95, 2009.
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May 28, 2015
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