Note: Separate PDQ summaries on Hodgkin’s Lymphoma During Pregnancy Treatment;
Childhood Hodgkin’s Lymphoma Treatment; and AIDS-Related Lymphoma Treatment are
Note: Estimated new cases and deaths from Hodgkin's lymphoma in the United States in 2007: 
- New cases: 8,190.
- Deaths: 1,070.
More than 75% of all newly diagnosed patients with adult Hodgkin’s lymphoma (HL) can be cured with combination chemotherapy and/or radiation therapy. National mortality has fallen more rapidly for adult HL than for any other malignancy.
Prognosis for a given patient depends on several factors. The most important
factors are the presence or absence of systemic symptoms, the stage of disease,
presence of large masses, and the quality and suitability of the treatment
administered. Other important factors are age (therapy for very young children
requires special attention), sex, erythrocyte sedimentation rate, extent of abdominal involvement, hematocrit, and absolute
number of nodal sites of involvement.[1,2]
HL is the main cause of death over the first 15 years after treatment. By
15 to 20 years after therapy, the cumulative mortality from a second malignancy
will exceed the cumulative mortality from HL.[3,4,5]
- American Cancer Society.: Cancer Facts and Figures 2007. Atlanta, Ga: American Cancer Society, 2007. Also available online. Last accessed March 5, 2007.
- Cosset JM, Henry-Amar M, Meerwaldt JH, et al.: The EORTC trials for limited stage Hodgkin's disease. The EORTC Lymphoma Cooperative Group. Eur J Cancer 28A (11): 1847-50, 1992.
- Mauch PM, Kalish LA, Marcus KC, et al.: Long-Term Survival in Hodgkin's Disease Cancer J Sci Am 1 (1): 33-42, 1995.
- Aisenberg AC: Problems in Hodgkin's disease management. Blood 93 (3): 761-79, 1999.
- Aleman BM, van den Belt-Dusebout AW, Klokman WJ, et al.: Long-term cause-specific mortality of patients treated for Hodgkin's disease. J Clin Oncol 21 (18): 3431-9, 2003.