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Langerhans Cell Histiocytosis Treatment (PDQ®): Treatment - Patient Information [NCI] - Stages of LCH

There is no staging system for Langerhans cell histiocytosis (LCH).

The extent or spread of cancer is usually described as stages. There is no staging system for LCH.

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Treatment of LCH is based on where LCH cells are found in the body and how many body systems are affected.

LCH is described as single-system disease or multisystem disease, depending on how many body systems are affected:

  • Single-system LCH: LCH is found in one part of an organ or body system (unifocal) or in more than one part of that organ or body system (multifocal). Bone is the most common single place for LCH to be found.
  • Multisystem LCH: LCH occurs in two or more organs or body systems or may be spread throughout the body. Multisystem LCH is less common than single-system LCH.

LCH may affect low-risk organs or high-risk organs:

  • Low-risk organs include the skin, bone, lungs, lymph nodes, gastrointestinal tract, pituitary gland, and central nervous system (CNS).
  • High-risk organs include the liver, spleen, and bone marrow.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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