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Laryngeal Cancer Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options by Stage

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Stage III Laryngeal Cancer

Treatment of stage III laryngeal cancer depends on where cancer is found in the larynx.

If cancer is in the supraglottis or glottis, treatment may include the following:

  • Chemotherapy and radiation therapy given together.
  • Chemotherapy followed by chemotherapy and radiation therapy given together. Laryngectomy may be done if cancer remains.
  • Radiation therapy for patients who cannot be treated with chemotherapy and surgery. For tumors that do not respond to radiation, total laryngectomy may be done.
  • Surgery, which may be followed by radiation therapy.
  • A clinical trial of radiation therapy.
  • A clinical trial of chemotherapy, radiosensitizers, or radiation therapy.
  • A clinical trial of chemoprevention.

If cancer is in the subglottis, treatment may include the following:

  • Laryngectomy plus total thyroidectomy and removal of lymph nodes in the throat, usually followed by radiation therapy.
  • Radiation therapy with or without surgery.
  • A clinical trial of chemotherapy, radiosensitizers, or radiation therapy.
  • A clinical trial of chemoprevention.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III laryngeal cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

Stage IV Laryngeal Cancer

Treatment of stage IV laryngeal cancer depends on where cancer is found in the larynx.

If cancer is in the supraglottis or glottis, treatment may include the following:

  • Chemotherapy and radiation therapy given together.
  • Chemotherapy followed by chemotherapy and radiation therapy given together. Laryngectomy may be done if cancer remains.
  • Radiation therapy for patients who cannot be treated with chemotherapy and surgery. For tumors that do not respond to radiation, total laryngectomy may be done.
  • Surgery followed by radiation therapy. Chemotherapy may be given with the radiation therapy.
  • A clinical trial of radiation therapy.
  • A clinical trial of chemotherapy, radiosensitizers, or radiation therapy.
  • A clinical trial of chemoprevention.
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