Skip to content
My WebMD Sign In, Sign Up

Cancer Health Center

Font Size

Late Effects of Treatment for Childhood Cancer (PDQ®): Treatment - Patient Information [NCI] - Musculoskeletal System

Bone and joint

Bone and joint late effects are more likely to occur after treatment for certain childhood cancers.

Recommended Related to Cancer

Stage IV and Recurrent Gastric Cancer

Standard treatment options: Palliative chemotherapy with: Fluorouracil (5-FU).[1,2,3]Epirubicin, cisplatin, and 5-FU (ECF).[4,5]Epirubicin, oxaliplatin, and capecitabine (EOX).[6]Cisplatin and 5-FU (CF).[7,3]Docetaxel, cisplatin, and 5-FU.[8]Etoposide, leucovorin, and 5-FU (ELF).[9]5-FU, doxorubicin, and methotrexate (FAMTX).[7] Trastuzumab, cisplatin, and either 5-FU or capecitabine in patients with HER2-positive tumors (3+ on immunohistochemistry [IHC] or fluorescence in situ...

Read the Stage IV and Recurrent Gastric Cancer article > >

Treatment for these and other childhood cancers may cause bone and joint late effects:

Surgery, chemotherapy, radiation therapy, and other treatments increase the risk of bone and joint late effects.

Radiation therapy

Radiation therapy can stop or slow the growth of bone. The type of bone and joint late effect depends on the part of the body that received radiation therapy. Radiation therapy may cause any of the following:

  • Changes in the way the face or skull form, especially when treatment is given to children before age 5 or when high-dose radiation is given.
  • Tooth or sinus problems.
  • Short stature (being shorter than normal).
  • Scoliosis (curving of the spine) or kyphosis (rounding of the spine).
  • One arm or leg is shorter than the other arm or leg.
  • Osteoporosis (weak or thin bones that can break easily).


Amputation or limb-sparing surgery to remove the cancer and prevent it from coming back may cause late effects depending on where the tumor was, age of the patient, and type of surgery. Health problems after amputation or limb-sparing surgery may include:

  • Having problems with activities of daily living.
  • Not being able to be as active as normal.
  • Chronic pain or infection.
  • Problems with the way prosthetics fit or work.
  • Broken bone.
  • One arm or leg is shorter than the other.

Studies show no difference in quality of life in childhood cancer survivors who had amputation compared to those who had limb-sparing surgery.

Chemotherapy and other drug therapy

Risk may be increased in childhood cancer survivors who receive anticancer therapy that includes methotrexate or corticosteroids or glucocorticoids such as dexamethasone. Drug therapy may cause any of the following:

  • Osteoporosis (weak or thin bones that can break easily).
  • Osteonecrosis (one or more parts of a bone dies from a lack of blood flow), especially in the hip or knee.

Stem cell transplant

A stem cell transplant can affect the bone and joints in different ways:

  • Total-body irradiation (TBI) given as part of a stem cell transplant may affect the body's ability to make growth hormone and cause short stature (being shorter than normal).
  • Osteochondroma (a benign tumor of the long bones) may form.
  • Chronic graft-versus-host disease may occur after a stem cell transplant and cause joint contractures (tightening of the muscles that causes the joint to shorten and become very stiff).

Possible signs of bone and joint late effects include bone and joint pain.

These symptoms may be caused by bone and joint late effects:

  • Swelling over a bone or bony part of the body.
  • Pain in a bone or joint.
  • Redness or warmth over a bone or joint.
  • Joint stiffness or trouble moving normally.
  • A bone that breaks for no known reason or breaks easily.
  • Short stature (being shorter than normal).
  • One side of the body looks higher than the other side or the body tilts to one side.
  • Always sitting or standing in a slouching position or having the appearance of a hunched back.

WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
Next Article:

Today on WebMD

Building a Support System
cancer fighting foods
precancerous lesions slideshow
quit smoking tips
Jennifer Goodman Linn self-portrait
what is your cancer risk
colorectal cancer treatment advances
breast cancer overview slideshow
prostate cancer overview
lung cancer overview slideshow
ovarian cancer overview slideshow
Actor Michael Douglas