Late effects are health problems that occur months or years after treatment has ended.
The cancer itself or the treatment of cancer may cause health problems for childhood cancer survivors months or years after successful treatment has ended. Cancer treatments may harm the body's organs, bones, or tissues and cause health problems later in life. These health problems are called late effects. Treatments that may cause late effects include surgery, chemotherapy, radiation therapy, or stem cell transplant.
Note: Separate PDQ summaries on Oral Cancer Prevention and Lip and Oral Cavity Cancer Treatment are also available.
There is inadequate evidence to establish whether screening would result in a decrease in mortality from oral cancer.
Magnitude of Effect: No evidence of benefit or harm.
Study Design: Evidence obtained from one randomized controlled trial.
Internal Validity: Poor.
Consistency: Not applicable (N/A).
Doctors are studying the late effects caused by cancer treatment. They are working to improve treatments and stop or lessen late effects. While most late effects are not life-threatening, they may cause serious problems that affect health and quality of life.
Late effects in childhood cancer survivors are both physical and emotional.
Late effects in childhood cancer survivors may affect the following:
Organs, tissues, and body function.
Growth and development.
Mood, feelings, and actions.
Thinking, learning, and memory.
Social and psychological adjustment.
Risk of second cancers.
There are three important factors that affect the risk of late effects.
Many childhood cancer survivors will have late effects. The risk of late effects depends on factors related to the patient, tumor, and treatment. These include the following:
Type of cancer.
Where the tumor is in the body.
How the tumor affects the way tissues and organs work.
Health problems the child had before being diagnosed with cancer.
The child's age at diagnosis and treatment.
Length of time since diagnosis and treatment.
Changes in hormone levels.
Family history of cancer or other conditions.
The chance of having late effects increases over time.
New treatments for childhood cancer have decreased the number of deaths from the primary cancer. However, the number of late effects in childhood cancer survivors increases with longer time since treatment and with older age. Survivors may not live as long as people who did not have cancer. The most common causes of death in childhood cancer survivors are: