Late effects are health problems that occur months or years after treatment has ended.
The cancer itself or the treatment of cancer may cause health problems for childhood cancer survivors months or years after successful treatment has ended. Cancer treatments may harm the body's organs, bones, or tissues and cause health problems later in life. These health problems are called late effects. Treatments that may cause late effects include surgery, chemotherapy, radiation therapy, or stem cell transplant.
Milk thistle is a plant whose fruit and seeds are used to make remedies for liver and bile duct ailments (see Question 1).
The active ingredient found in milk thistle is silymarin, an antioxidant that, among other things, protects against cell damage and stimulates repair of liver tissue (see Question 1 and Question 5).
Milk thistle has been studied in laboratory cell lines and animal tumors for its potential to make chemotherapy less toxic and more effective, and to slow the growth...
Doctors are studying the late effects caused by cancer treatment. They are working to improve treatments and stop or lessen late effects. While most late effects are not life-threatening, they may cause serious problems that affect health and quality of life.
Late effects in childhood cancer survivors are both physical and emotional.
Late effects in childhood cancer survivors may affect the following:
Organs, tissues, and body function.
Growth and development.
Mood, feelings, and actions.
Thinking, learning, and memory.
Social and psychological adjustment.
Risk of second cancers.
There are three important factors that affect the risk of late effects.
Many childhood cancer survivors will have late effects. The risk of late effects depends on factors related to the patient, tumor, and treatment. These include the following:
Type of cancer.
Where the tumor is in the body.
How the tumor affects the way tissues and organs work.
Type of surgery.
Chemotherapy type, dose, and schedule.
Radiation therapy type, part of the body treated, and dose.
Use of two or more types of treatment at the same time.
Blood product transfusion.
The child's gender.
The child's age at diagnosis and treatment.
Length of time since diagnosis and treatment.
Certain changes in the child's genes.
Being exposed to substances in the environment that cause cancer.
Family history of cancer or other conditions.
Health problems the child had before being diagnosed with cancer.
The chance of having late effects increases over time.
New treatments for childhood cancer have decreased the number of deaths from the primary cancer. However, the number of late effects in childhood cancer survivors increases with longer time since treatment and with older age. Survivors may not live as long as people who did not have cancer. The most common causes of death in childhood cancer survivors are: