Skip to content

Cancer Health Center

Font Size

Merkel Cell Carcinoma Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Merkel Cell Carcinoma

Table 4. Regional Lymph Nodes (N)a

a Reprinted with permission from AJCC: Merkel cell carcinoma. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 315-23.
b Clinical detection of nodal disease may be via inspection, palpation, and/or imaging.
c Micrometastases are diagnosed after sentinel or elective lymphadenectomy.
d Macrometastases are defined as clinically detectable nodal metastases confirmed by therapeutic lymphadenectomy or needle biopsy.
e In transit metastasis: a tumor distinct from the primary lesion and located either (1) between the primary lesion and the draining regional lymph nodes or (2) distal to the primary lesion.
NXRegional lymph nodes cannot be assessed.
N0No regional lymph nodes metastasis.
cN0Nodes negative by clinical examb(no pathologic node exam performed).
pN0Nodes negative by pathologic exam.
N1Metastases in regional lymph node(s).
N1aMicrometastasis.c
N1bMacrometastasis.d
N2In transit metastasis.e

Table 5. Distant Metastasis (M)a

a Reprinted with permission from AJCC: Merkel cell carcinoma. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 315-23.
M0No distant metastasis.
M1Metastases beyond regional lymph nodes.
M1aMetastases to skin, subcutaneous tissues, or distant lymph nodes.
M1bMetastasis to lung.
M1cMetastases to all other visceral sites.

Table 6. Anatomic Stage/Prognostic Groupsa

StageTNM
a Reprinted with permission from AJCC: Merkel cell carcinoma. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 315-23.
0TisN0M0
IAT1pN0M0
IBT1cN0M0
IIAT2/T3pN0M0
IIBT2/T3cN0M0
IICT4N0M0
IIIAAny TN1aM0
IIIBAny TN1b/N2M0
IVAny TAny NM1

Before the new AJCC consensus staging system was published, the most recent MSKCC four-stage system was favored because it was based on the largest number of patients and was the best validated.[1] The stages in the MSKCC system included:

  • Stage I: local disease <2 cm.
  • Stage II: local disease ≥2 cm.
  • Stage III: regional nodal disease.
  • Stage IV: distant metastatic disease.
1|2|3
Next Article:

Today on WebMD

Colorectal cancer cells
A common one in both men and women.
Lung cancer xray
See it in pictures, plus read the facts.
 
sauteed cherry tomatoes
Fight cancer one plate at a time.
Ovarian cancer illustration
Do you know the symptoms?
 
Jennifer Goodman Linn self-portrait
Blog
what is your cancer risk
HEALTH CHECK
 
colorectal cancer treatment advances
Video
breast cancer overview slideshow
SLIDESHOW
 
prostate cancer overview
SLIDESHOW
lung cancer overview slideshow
SLIDESHOW
 
ovarian cancer overview slideshow
SLIDESHOW
Actor Michael Douglas
Article