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    Metastatic Squamous Neck Cancer With Occult Primary Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Metastatic Squamous Neck Cancer With Occult Primary

    Definitions of TNM

    The American Joint Committee on Cancer has designated staging by TNM classification to define metastatic squamous neck cancer with occult primary.[1]

    Table 1. Regional Lymph Nodes (N)a

    a Reprinted with permission from AJCC: Head and neck. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 21-8.
    b A designation of "U" or "L" may be used for any N stage to indicate metastasis above the lower border of the cricoid (U) or below the lower border of the cricoid (L). Similarly, clinical/radiological ECS should be recorded as E-- or E+, and histopathologic ECS should be designated En, Em, or Eg.
    NX Regional lymph nodes cannot be assessed.
    N0 No regional lymph node metastasis.
    N1b Metastasis in a single ipsilateral lymph node, ≤3 cm in greatest dimension.
    N2b Metastasis in a single isilateral lymph node, >3 cm but not >6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none >6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none >6 cm in greatest dimension.
    N2ab Metastasis in single ipsilateral lymph node >3 cm but not >6 cm in greatest dimension.
    N2bb Metastases in multiple ipsilateral lymph nodes, none >6 cm in greatest dimension.
    N2cb Metastases in bilateral or contralateral lymph nodes, none >6 cm in greatest dimension.
    N3b Metastasis in a lymph node >6 cm in greatest dimension.

    Table 2. Distant Metastasis (M)a

    a Reprinted with permission from AJCC: Head and neck. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 21-8.
    M0 No distant metastasis.
    M1 Distant metastasis.

    Untreated

    Untreated metastatic squamous neck cancer with occult primary means that a patient is newly diagnosed and has had no prior treatment except supportive care.

    References:

    1. Head and neck sites. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 21-8.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: 8/, 015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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