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    Mycosis Fungoides and the Sézary Syndrome Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Recurrent Mycosis Fungoides and the Sézary Syndrome

    Treatment of recurrent mycosis fungoides and the Sézary syndrome is usually within a clinical trial and may include the following:

    • Radiation therapy to skin lesions or all the skin on the body (TSEB).
    • Topical chemotherapy.
    • PUVA therapy, to relieve symptoms and improve the quality of life.
    • PUVA therapy with biologic therapy (interferon).
    • Ultraviolet B (UVB) radiation therapy.
    • Topical corticosteroid therapy, to relieve symptoms and improve the quality of life.
    • Extracorporeal photochemotherapy.
    • Targeted therapy with a radiolabeled monoclonal antibody.
    • Targeted therapy with a monoclonal antibody (alemtuzumab or denileukin diftitox).
    • Retinoid therapy.
    • Chemotherapy.
    • High-dose chemotherapy with stem cell transplant.
    • Targeted therapy with vorinostat, romidepsin, or other histone deacetylase (HDAC) inhibitors.
    • Targeted therapy with pralatrexate.

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent mycosis fungoides/Sezary syndrome. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

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    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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