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Mycosis Fungoides and the Sézary Syndrome Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Changes to This Summary (08 / 12 / 2013)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

General Information About Mycosis Fungoides and the Sézary Syndrome

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Overview

Good communication between patients, family caregivers, and the health care team is very important in cancer care. Good communication between patients with cancer, family caregivers, and the health care team helps improve patients' well-being and quality of life. Communicating about concerns and decision making is important during all phases of treatment and supportive care for cancer. The goals of good communication in cancer care are to: Build a trusting relationship between the patient,...

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Revised text to state that the Sézary syndrome (SS) presents with generalized erythroderma (T4) and peripheral blood involvement. Also added text to state that there is consensus that patients with SS have a poor prognosis (cited Kubica et al. as reference 12). Added text to state that a retrospective analysis of 100 cases with large-cell transformation found reduced disease-specific survival with extracutaneous transformation, increased extent of skin lesions, and CD30 negativity (cited Benner et al. as reference 15).

Treatment Option Overview

Added text to include pralatrexate as a treatment option for patients with mycosis fungoides and the Sézary syndrome (MF/SS) (cited Horwitz et al. as reference 4).

Stage I Mycosis Fungoides

Added Navi et al. as reference 11.

Added text to include pralatrexate as a treatment option for patients with stage I mycosis fungoides (cited Horwitz et al. as reference 22).

Stage II Mycosis Fungoides

Added Navi et al. as reference 9.

Added text to include pralatrexate as a treatment option for patients with stage II mycosis fungoides (cited Horwitz et al. as reference 21).

Stage III Mycosis Fungoides

Added text to include oral methotrexate as a treatment option for patients with stage III mycosis fungoides (cited Zackheim et al. as reference 24).

Added text to include pralatrexate as a treatment option for patients with stage III mycosis fungoides (cited Horwitz et al. as reference 28).

Stage IV Mycosis Fungoides and the Sézary Syndrome

Added Navi et al. as reference 7.

Added text to include oral methotrexate as a treatment option for patients with stage IV MF/SS (cited Zackheim et al. as reference 26).

Added text to include pralatrexate as a treatment option for patients with stage IV MF/SS (cited Horwitz et al. as reference 30).

Recurrent Mycosis Fungoides and the Sézary Syndrome

Added Schlaak et al. as reference 13.

Added text to include pralatrexate as a treatment option for patients with recurrent MF/SS (cited Horwitz et al. as reference 16).

This summary is written and maintained by the PDQ Adult Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: September 04, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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