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    Mycosis Fungoides and the Sézary Syndrome Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Option Overview

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    See Drugs Approved for Non-Hodgkin Lymphoma for more information. (Mycosis fungoides and the Sézary syndrome are types of non-Hodgkin lymphoma.)

    Targeted therapy

    Targeted therapy is a treatment that uses drugs or other substances to identify and attack specific cancer cells without harming normal cells. Monoclonal antibody therapy and other types of targeted therapies are used to treat mycosis fungoides and the Sézary syndrome.

    Alemtuzumab and denileukin diftitox are monoclonal antibodies used to treat mycosis fungoides and the Sézary syndrome. Monoclonal antibody therapy uses antibodies made in the laboratory, from a single type of immune system cell. These antibodies can identify substances on cancer cells or normal substances that may help cancer cells grow. The antibodies attach to the substances and kill the cancer cells, block their growth, or keep them from spreading. Monoclonal antibodies are given by infusion. They may be used alone or to carry drugs, toxins, or radioactive material directly to cancer cells.

    Vorinostat and romidepsin are two of the histone deacetylase (HDAC) inhibitors used to treat mycosis fungoides and the Sézary syndrome. HDAC inhibitors cause a chemical change that stops tumor cells from dividing.

    Pralatrexate is a dihydrofolate reductase (DHFR) inhibitor used to treat mycosis fungoides and the Sézary syndrome. It builds up in cancer cells and stops them from using folate, a nutrient needed for cells to divide. Pralatrexate may slow the growth of tumors and kill cancer cells.

    See Drugs Approved for Non-Hodgkin Lymphoma for more information. (Mycosis fungoides and the Sézary syndrome are types of non-Hodgkin lymphoma.)

    New types of treatment are being tested in clinical trials.

    This summary section describes treatments that are being studied in clinical trials. It may not mention every new treatment being studied. Information about clinical trials is available from the NCI Web site.

    Ultraviolet B radiation therapy

    Ultraviolet B (UVB) radiation therapy uses a special lamp or laser that directs UVB radiation at the skin.

    High-dose chemotherapy and radiation therapy with stem cell transplant

    This treatment is a method of giving high doses of chemotherapy and radiation therapy and replacing blood-forming cells destroyed by the cancer treatment. Stem cells (immature blood cells) are removed from the bone marrow or blood of the patient or a donor and are frozen and stored. After therapy is completed, the stored stem cells are thawed and given back to the patient through an infusion. These reinfused stem cells grow into (and restore) the body's blood cells.

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