Anaplastic large-cell lymphoma (ALCL) is a rare type of blood cancer. It's more common in young people, mostly boys. It doesn't run in families.
ALCL is a serious illness. It can be fast growing, and it often returns. Treatments can help you fight it. Other therapies can help you feel better.
Scientists are still looking for new and better ways to treat both the disease and the symptoms.
When you have lymphoma, cells called lymphocytes grow out of control. These are white blood cells that usually...
Although cytogenetic abnormalities are found in as many as 80% of the patients with aCML, none is specific.[1,2,3,5] No Philadelphia chromosome or BCR/ABL fusion gene exists.
The exact incidence of aCML is unknown. The median age at the time of diagnosis of this rare leukemic disorder has been reported to be in the seventh or eighth decade of life.[1,2,3]
Morphologically, aCML is characterized by myelodysplasia associated with bone marrow and peripheral blood patterns similar to chronic myelogenous leukemia, but cytogenetically it lacks a Philadelphia chromosome or BCR/ABL fusion gene. The white blood cell count in the peripheral blood is variable. Median values range from 35 × 109 /L to 96 × 109 /L, and some patients may have white blood cell counts greater than 300 × 109 /L.[1,2,3,5] Blasts in the peripheral blood typically account for less than 5% of the white blood cells. Immature neutrophils usually total 10% to 20% or more. The percentage of monocytes is rarely more than 10%. Minimal basophilia may be present.[1,2,3,5] Nuclear abnormalities, such as acquired Pelger-Huët anomaly, may be seen in the neutrophils. Moderate anemia (often showing changes indicative of dyserythropoiesis) and thrombocytopenia are common.[1,2,3,4] Bone marrow findings include the following: [1,2,3,5]
Blast count less than 20%.
Erythroid precursors accounting for more than 30% of marrow cells with dyserythropoiesis present (in some cases).