Myelodysplastic Syndromes Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Relapsed or Refractory Myelodysplastic Syndromes
Lack of response or progression after the use of erythropoiesis-stimulating agents is not considered relapsed or refractory myelodysplastic syndromes (MDS).
With the exception of the use of lenalidomide for low-risk patients with abnormalities of chromosome 5, there are no clinical trials informing the appropriate selection of current therapies for patients with specific subtypes of MDS. Patients who have ceased to respond or did not respond to one therapy are frequently offered another from the therapies described in the previous sections. Retrospective data suggest that patients who do not respond or have ceased responding to DNA methyltransferase inhibitors have a median survival of only 4 to 6 months.[1,2] Relapsed patients should be considered for enrollment in clinical trials.
For more information from the National Cancer Institute about chronic lymphocytic leukemia, see the following:
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What You Need to Know About™ Leukemia
Drugs Approved for Chronic Lymphocytic Leukemia
Targeted Cancer Therapies
Understanding Cancer Series: Targeted Therapies
Biological Therapies for Cancer: Questions and Answers
For general cancer information and other resources from the National Cancer Institute, see the following:
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Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with adult myelodysplastic syndromes. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
Prébet T, Gore SD, Esterni B, et al.: Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure. J Clin Oncol 29 (24): 3322-7, 2011.
Jabbour E, Garcia-Manero G, Batty N, et al.: Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy. Cancer 116 (16): 3830-4, 2010.