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Treatment of Newly Diagnosed Childhood Brain and Spinal Cord Tumors

Childhood Astrocytoma

Refer to the PDQ summary on Childhood Astrocytomas Treatment for more information.

Recommended Related to Cancer

High-Stage Childhood Anaplastic Large Cell Lymphoma

Note: Some citations in the text of this section are followed by a level of evidence. The PDQ Editorial Boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.) Children and adolescents with high-stage (stage III or IV) anaplastic large cell lymphoma (ALCL) have a disease-free survival of approximately 60% to 75%.[1,2,3,4,5] It is unclear...

Read the High-Stage Childhood Anaplastic Large Cell Lymphoma article > >

Current Clinical Trials

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with childhood astrocytoma. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site.

Childhood Brain Stem Glioma

Refer to the PDQ summary on Childhood Brain Stem Glioma Treatment for more information

Current Clinical Trials

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with childhood brain stem glioma. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site.

Childhood Central Nervous System (CNS) Embryonal Tumors

Refer to the PDQ summary on Childhood Central Nervous System Embryonal Tumors Treatment for more information.

Current Clinical Trials

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with childhood embryonal tumor. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

General information about clinical trials is also available from the NCI Web site.

Childhood CNS Germ Cell Tumors

Surgery, other than biopsy to establish the diagnosis, rarely plays a role in the treatment of CNS germinomas. The role of surgical resection for nongerminomatous germ cell tumors and teratomas remains to be defined.[1] For germinomas, irradiation with doses of 45 Gy to 54 Gy to the tumor and 21 Gy to 36 Gy to the whole brain and spine is usually curative. In selected cases, germinoma can be effectively treated with ventricular field radiation therapy and at lower dose levels (21-30 Gy) following response to chemotherapy.[1,2] Although experience with pre-irradiation chemotherapy has shown that most of these tumors respond to cyclophosphamide or platinum-containing regimens with or without etoposide, the definitive role of chemotherapy has yet to be determined.[1] Disseminated germinomas are treated with craniospinal irradiation, alone or in combination with chemotherapy.[3,4] The usual dose to the tumor is 45 Gy to 54 Gy with 27 Gy to 36 Gy to the whole brain and spine. Nongerminomatous germ cell tumors (e.g., embryonal carcinomas, yolk cell tumors, choriocarcinomas, and mixed germ cell tumors) may respond to chemotherapeutic agents (e.g., cisplatin or carboplatin, etoposide, and cyclophosphamide) as do such histologies outside of the CNS. Optimal combination of agents and the timing of chemotherapy in relation to radiation therapy remain to be determined.[5,6,7]

Current Clinical Trials

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with childhood central nervous system germ cell tumor. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.

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WebMD Public Information from the National Cancer Institute

Last Updated: October 07, 2011
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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