Hypercalcemia occurs more frequently in some malignancies (e.g., breast cancer, multiple myeloma, and squamous cell carcinoma of the lung) than in others. Within each disease type, the incidence of hypercalcemia varies greatly in reported series. The frequency of hypercalcemia in some of the commonly involved neoplastic disorders is shown in Table 1.
Table 1. Incidence of Hypercalcemia by Tumor Typea