Pain (PDQ®): Supportive care - Patient Information [NCI] - Management with Drugs
Drugs Used with Pain Medications
Other drugs may be given at the same time as the pain medication. This is done to increase the effectiveness of the pain medication, treat symptoms, and relieve specific types of pain. These drugs include antidepressants, anticonvulsants, local anesthetics, corticosteroids, bisphosphonates, and stimulants. The use of cannabinoids added to pain medicine is being studied for cancer-related pain. A monoclonal antibody called denosumab is used to prevent broken bones and other bone problems caused by solid tumors that have metastasized (spread) to bone. There are great differences in how patients respond to these drugs. Side effects are common and should be reported to the doctor.
The use of bisphosphonates may cause severe and sometimes disabling pain in the bones, joints, and/or muscles. This pain may develop after these drugs are used for days, months, or years, as compared with the fever, chills, and discomfort that may occur when intravenous bisphosphonates are first given. If severe muscle or bone pain develops, bisphosphonate therapy may need to be stopped.
The use of bisphosphonates is also linked to the risk of bisphosphonate-associated osteonecrosis (BON). See the PDQ summary on Oral Complications of Chemotherapy and Head/Neck Radiation for more information on BON.