Childhood extracranial germ cell tumors form from developing sperm or egg cells that travel to parts of the body other than the brain.
As a fetus develops, certain cells form sperm in the testicles or eggs in the ovaries. Sometimes these cells travel to other parts of the body and grow into germ cell tumors. This summary is about germ cell tumors that form in parts of the body that are extracranial (outside the brain). Extracranial germ cell tumors are most common in teenagers 15 to 19 years old.
This complementary and alternative medicine (CAM) information summary provides an overview of the use of laetrile as a treatment for people with cancer. The summary includes a history of laetrile research, a review of laboratory studies, the results of clinical trials, and possible side effects of laetrile use.
This summary contains the following key information:
Laetrile is another name for the chemical amygdalin, which is found in the pits of many fruits and in numerous plants.
Choriocarcinomas: Tumors that make a hormone called beta-human chorionic gonadotropin (β-hCG).
Childhood extracranial germ cell tumors are grouped as gonadal or extragonadal.
Malignant extracranial germ cell tumors are grouped into gonadal and extragonadal.
Gonadal Germ Cell Tumors
Gonadal germ cell tumors form in the testicles or ovaries.
Testicular Germ Cell Tumors
Testicular germ cell tumors usually occur before the age of 4 years or in teenagers and young adults.
Testicular germ cell tumors in teenagers and young adults are different from those that form in early childhood. They are more like testicular cancer in adults. Testicular germ cell tumors are divided into two main types, seminoma and nonseminoma. (See the PDQ summary on Testicular Cancer Treatment for more information.)
Seminoma: These tumors make a hormone called beta-human chorionic gonadotropin (β-hCG).
Nonseminoma: These tumors are usually large and cause symptoms. They tend to grow and spread more quickly than seminomas.