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Treatment Options for Childhood Extracranial Germ Cell Tumors

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    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with childhood malignant testicular germ cell tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

    Malignant Ovarian Germ Cell Tumors

    Treatment of childhood malignant ovarian germ cell tumors in young girls may include the following:

    • Surgery (unilateral salpingo-oophorectomy) followed by watchful waiting for stage I dysgerminoma or immature teratoma tumors. Chemotherapy may be given if the tumor comes back.
    • Surgery (unilateral salpingo-oophorectomy) followed by combination chemotherapy for stages II-IV tumors.
    • Chemotherapy to make the tumor smaller, followed by surgery (unilateral salpingo-oophorectomy).
    • Surgery (tumor debulking) followed by chemotherapy.
    • A clinical trial of fewer cycles of chemotherapy after surgery.
    • A clinical trial of surgery (unilateral salpingo-oophorectomy) followed by watchful waiting for stage I tumors that are not a dysgerminoma or immature teratoma.

    The treatment for adolescents and young adults with ovarian germ cell tumor is similar to the treatment for adults. (See the PDQ treatment summary on Ovarian Germ Cell Tumors for more information.)

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with childhood malignant ovarian germ cell tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

    Malignant Extragonadal Germ Cell Tumors

    Treatment of childhood extragonadal malignant germ cell tumors may include the following:

    • Surgery to remove tumors in the mediastinum (the area between the lungs).
    • Surgery followed by combination chemotherapy.
    • Combination chemotherapy followed by surgery.
    • Chemotherapy only.
    • A clinical trial of a new chemotherapy regimen.

    (See the PDQ treatment summary on Extragonadal Germ Cell Tumors for more information.)

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with childhood extragonadal germ cell tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

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