Skip to content
My WebMD Sign In, Sign Up

Cancer Health Center

Font Size

Sexuality and Reproductive Issues (PDQ®): Supportive care - Health Professional Information [NCI] - Fertility Issues


General information about clinical trials is also available from the NCI Web site.


  1. Zebrack BJ, Casillas J, Nohr L, et al.: Fertility issues for young adult survivors of childhood cancer. Psychooncology 13 (10): 689-99, 2004.
  2. Canada AL, Schover LR: Research promoting better patient education on reproductive health after cancer. J Natl Cancer Inst Monogr (34): 98-100, 2005.
  3. Howell S, Shalet S: Gonadal damage from chemotherapy and radiotherapy. Endocrinol Metab Clin North Am 27 (4): 927-43, 1998.
  4. Yarbro CH, Perry MC: The effect of cancer therapy on gonadal function. Semin Oncol Nurs 1 (1): 3-8, 1985.
  5. Fisher B, Dignam J, Mamounas EP, et al.: Sequential methotrexate and fluorouracil for the treatment of node-negative breast cancer patients with estrogen receptor-negative tumors: eight-year results from National Surgical Adjuvant Breast and Bowel Project (NSABP) B-13 and first report of findings from NSABP B-19 comparing methotrexate and fluorouracil with conventional cyclophosphamide, methotrexate, and fluorouracil. J Clin Oncol 14 (7): 1982-92, 1996.
  6. Goodwin PJ, Ennis M, Pritchard KI, et al.: Risk of menopause during the first year after breast cancer diagnosis. J Clin Oncol 17 (8): 2365-70, 1999.
  7. Lamb MA: Effects of chemotherapy on fertility in long-term survivors. Dimens Oncol Nurs 5 (4): 13-6, 1991 Winter.
  8. Longhi A, Macchiagodena M, Vitali G, et al.: Fertility in male patients treated with neoadjuvant chemotherapy for osteosarcoma. J Pediatr Hematol Oncol 25 (4): 292-6, 2003.
  9. Simon B, Lee SJ, Partridge AH, et al.: Preserving fertility after cancer. CA Cancer J Clin 55 (4): 211-28; quiz 263-4, 2005 Jul-Aug.
  10. Lee S, Kil WJ, Chun M, et al.: Chemotherapy-related amenorrhea in premenopausal women with breast cancer. Menopause 16 (1): 98-103, 2009 Jan-Feb.
  11. DeSantis M, Albrecht W, Höltl W, et al.: Impact of cytotoxic treatment on long-term fertility in patients with germ-cell cancer. Int J Cancer 83 (6): 864-5, 1999.
  12. Soloway CT, Soloway MS, Kim SS, et al.: Sexual, psychological and dyadic qualities of the prostate cancer 'couple'. BJU Int 95 (6): 780-5, 2005.
  13. Schover LR: Sexuality and Fertility After Cancer. New York, NY: John Wiley and Sons, 1997.
  14. Socié G, Salooja N, Cohen A, et al.: Nonmalignant late effects after allogeneic stem cell transplantation. Blood 101 (9): 3373-85, 2003.
  15. Gradishar WJ, Schilsky RL: Effects of cancer treatment on the reproductive system. Crit Rev Oncol Hematol 8 (2): 153-71, 1988.
  16. Donnez J, Bassil S: Indications for cryopreservation of ovarian tissue. Hum Reprod Update 4 (3): 248-59, 1998 May-Jun.
  17. Green DM, Kawashima T, Stovall M, et al.: Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study. J Clin Oncol 27 (16): 2677-85, 2009.
  18. Morice P, Thiam-Ba R, Castaigne D, et al.: Fertility results after ovarian transposition for pelvic malignancies treated by external irradiation or brachytherapy. Hum Reprod 13 (3): 660-3, 1998.
  19. Linsenmeyer TA: Management of male infertility. In: Sipski ML, Alexander CJ, eds.: Sexual Function in People With Disability and Chronic Illness. Gaithersburg, Md: Aspen Publishers, Inc, 1997, pp 487-510.
  20. Schrader M, Mller M, Sofikitis N, et al.: "Onco-tese": testicular sperm extraction in azoospermic cancer patients before chemotherapy-new guidelines? Urology 61 (2): 421-5, 2003.
  21. Bahadur G, Ling KL, Hart R, et al.: Semen quality and cryopreservation in adolescent cancer patients. Hum Reprod 17 (12): 3157-61, 2002.
  22. Saito K, Suzuki K, Iwasaki A, et al.: Sperm cryopreservation before cancer chemotherapy helps in the emotional battle against cancer. Cancer 104 (3): 521-4, 2005.
  23. Welner SL: Management of female infertility. In: Sipski ML, Alexander CJ, eds.: Sexual Function in People With Disability and Chronic Illness. Gaithersburg, Md: Aspen Publishers, Inc, 1997, pp 537-556.
  24. Fabbri R, Venturoli S, D'Errico A, et al.: Ovarian tissue banking and fertility preservation in cancer patients: histological and immunohistochemical evaluation. Gynecol Oncol 89 (2): 259-66, 2003.
  25. Pal L, Leykin L, Schifren JL, et al.: Malignancy may adversely influence the quality and behaviour of oocytes. Hum Reprod 13 (7): 1837-40, 1998.
  26. Meirow D, Levron J, Eldar-Geva T, et al.: Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med 353 (3): 318-21, 2005.
  27. Grifo JA, Noyes N: Delivery rate using cryopreserved oocytes is comparable to conventional in vitro fertilization using fresh oocytes: potential fertility preservation for female cancer patients. Fertil Steril 93 (2): 391-6, 2010.
  28. Fosså SD, Magelssen H, Melve K, et al.: Parenthood in survivors after adulthood cancer and perinatal health in their offspring: a preliminary report. J Natl Cancer Inst Monogr (34): 77-82, 2005.
  29. Blackhall FH, Atkinson AD, Maaya MB, et al.: Semen cryopreservation, utilisation and reproductive outcome in men treated for Hodgkin's disease. Br J Cancer 87 (4): 381-4, 2002.
  30. Ragni G, Somigliana E, Restelli L, et al.: Sperm banking and rate of assisted reproduction treatment: insights from a 15-year cryopreservation program for male cancer patients. Cancer 97 (7): 1624-9, 2003.
  31. Boyle KE, Vlahos N, Jarow JP: Assisted reproductive technology in the new millennium: part II. Urology 63 (2): 217-24, 2004.
  32. Kamischke A, Jürgens H, Hertle L, et al.: Cryopreservation of sperm from adolescents and adults with malignancies. J Androl 25 (4): 586-92, 2004 Jul-Aug.
  33. Damani MN, Master V, Meng MV, et al.: Postchemotherapy ejaculatory azoospermia: fatherhood with sperm from testis tissue with intracytoplasmic sperm injection. J Clin Oncol 20 (4): 930-6, 2002.
  34. Schover LR, Thomas AJ: Overcoming Male Infertility. New York, NY: John Wiley & Sons, 2000.

WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
Next Article:

Today on WebMD

Colorectal cancer cells
A common one in both men and women.
Lung cancer xray
See it in pictures, plus read the facts.
sauteed cherry tomatoes
Fight cancer one plate at a time.
Ovarian cancer illustration
Do you know the symptoms?
Jennifer Goodman Linn self-portrait
what is your cancer risk
colorectal cancer treatment advances
breast cancer overview slideshow
prostate cancer overview
lung cancer overview slideshow
ovarian cancer overview slideshow
Actor Michael Douglas