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    Genetics of Colorectal Cancer (PDQ®): Genetics - Health Professional Information [NCI] - Introduction

    Table 1. Estimated Relative and Absolute Risk of Developing Colorectal Cancer (CRC) continued...

    (Refer to the Interventions for FAP section and the Chemoprevention in LS section in the Major Genetic Syndromes section of this summary for more information about chemoprevention.)

    Modifying behavioral risk factors

    Several components of diet and behavior have been suggested, with various levels of consistency, to be risk factors for CRC. (Refer to the PDQ summary on Prevention of Colorectal Cancer for more information.) These lifestyle factors may represent potential means of prevention.[74,76,77] Expert groups differ on the interpretation of the evidence for some of these components.

    Little is known about whether these same factors are protective in people with a genetically increased risk of CRC. In one case-control study, low levels of physical activity, high caloric intake, and low vegetable intake were significantly related to cancer risk in people with no family history of CRC but showed no relationship in people with a family history, despite adequate statistical power to do so.[78]


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    Last Updated: May 28, 2015
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