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Vulvar Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Cellular Classification of Vulvar Cancer

Presented below is an adaptation of the histologic classification of vulvar disease and precursor lesions of cancer of the vulva developed by the International Society for the Study of Vulvar Disease.[1] This evidence summary deals with vulvar intraepithelial neoplasias (VIN) and invasive carcinomas.

Non-neoplastic epithelial disorders of skin and mucosa

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Overview

Note: Separate PDQ summaries on Endometrial Cancer Screening; Endometrial Cancer Treatment; and Uterine Sarcoma Treatment are also available. Intervention Associated With Decreased Risk Oral contraceptives Based on solid evidence, at least 1 year's use of oral contraceptives containing estrogen and progesterone decreases endometrial cancer risk, proportionate to duration of use. This benefit lasts at least 15 years after cessation.[1,2] Magnitude of Effect: Use of oral contraceptives...

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  • Lichen sclerosus (lichen sclerosus et atrophicus).
  • Squamous cell hyperplasia (formerly hyperplastic dystrophy).
  • Other dermatoses.

VIN

  • Usual type (high-grade 2 and 3).
  • Differentiated type (high-grade 3).

Paget disease of the vulva

  • Characteristic large pale cells in the epithelium and skin adnexa.

Other histologies

References:

  1. Sideri M, Jones RW, Wilkinson EJ, et al.: Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee. J Reprod Med 50 (11): 807-10, 2005.
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WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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