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Gastrointestinal Carcinoid Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Gastrointestinal Carcinoid Tumors

Definitions of TNM

The American Joint Committee on Cancer (AJCC) has designated staging by TNM classification to define neuroendocrine tumors.[1]

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This staging system is new for the 7th edition of the AJCC Cancer Staging Manual.[1]

Neuroendocrine Tumors: Stomach

Table 2. Primary Tumor (T)a

a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
TXPrimary tumor cannot be assessed.
T0No evidence of primary tumor.
TisCarcinomain situ /dysplasia (tumor size <0.5 mm), confined to mucosa.
T1Tumor invades lamina propria or submucosa and ≤1 cm in size.
T2Tumor invades muscularis propria or >1 cm in size.
T3Tumor penetrates subserosa.
T4Tumor invades visceral peritoneum (serosal) or other organs or adjacent structures.
For any T, add (m) for multiple tumors.

Table 3. Regional Lymph Nodes (N)a

a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
NXRegional lymph nodes cannot be assessed.
N0No regional lymph node metastasis.
N1Regional lymph node metastasis.

Table 4. Distant Metastases (M)a

a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
M0No distant metastases.
M1Distant metastasis.

Neuroendocrine Tumors: Duodenum/Ampulla/Jejunum/Ileum

Table 5. Primary Tumor (T)a

a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
b Tumor limited to ampulla of Vater for ampullary gangiocytic paraganglioma.
TXPrimary tumor cannot be assessed.
T0No evidence of primary tumor.
T1Tumor invades lamina propria or submucosa and size ≤1 cmb(small intestinal tumors); tumor ≤1 cm (ampullary tumors).
T2Tumor invades muscularis propria or size >1 cm (small intestinal tumors); tumor >1 cm (ampullary tumors).
T3Tumor invades through the muscularis propria into subserosal tissue without penetration of overlying serosa (jejunal or ileal tumors) or invades pancreas or retroperitoneum (ampullary or duodenal tumors) or into nonperitonealized tissues.
T4Tumor invades visceral peritoneum (serosa) or invades other organs.
For any T, add (m) for multiple tumors.

Table 6. Regional Lymph Nodes (N)a

a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
NXRegional lymph nodes cannot be assessed.
N0No regional lymph node metastasis.
N1Regional lymph node metastasis.
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