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Gastrointestinal Carcinoid Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Gastrointestinal Carcinoid Tumors

Table 7. Distant Metastases (M)a

a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
M0No distant metastases.
M1Distant metastasis.

Neuroendocrine Tumors: Colon or Rectum

Table 8. Primary Tumora

a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
TXPrimary tumor cannot be assessed.
T0No evidence of primary tumor.
T1Tumor invades lamina propria or submucosa and size ≤2 cm.
T1aTumor size <1 cm in greatest dimension.
T1bTumor size 1–2 cm in greatest dimension.
T2Tumor invades muscularis propria or size >2 cm with invasion of lamina propria or submucosa.
T3Tumor invades through the muscularis propria into the subserosa or into nonperitonealized pericolic or perirectal tissues.
T4Tumor invades peritoneum or other organs.
For any T, add (m) for multiple tumors.

Table 9. Regional Lymph Nodes (N)a

a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
NXRegional lymph nodes cannot be assessed.
N0No regional lymph node metastasis.
N1Regional lymph node metastasis.

Table 10. Distant Metastases (M)a

a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
M0No distant metastases.
M1Distant metastasis.

Table 11. Anatomic Stage/Prognostic Groups for Stomach, Duodenum/Ampulla/Jejunum/Ileum, and Colon or Rectuma

StageTNM
a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
0TisN0M0
IT1N0M0
IIAT2N0M0
IIBT3N0M0
IIIAT4N0M0
IIIBAny TN1M0
IVAny TAny NM1

Appendiceal Carcinoids

A new classification is added for carcinoid tumors that were not classified previously by TNM. This is a new classification. There are substantial differences between the classification schemes of appendiceal carcinomas and carcinoids and between appendiceal carcinoids and other well-differentiated gastrointestinal neuroendocrine tumors (carcinoids).[2]

Serum chromogranin A is identified as a significant prognostic factor.[2]

Table 12. Primary Tumor (T)a,b

a Reprinted with permission from AJCC: Appendix. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 133-41.
b Tumor that is adherent to other organs or structures, grossly, is classified cT4. However, if no tumor is present in the adhesion, microscopically, the classification should be classified pT1–3 depending on the anatomical depth of wall invasion.
c Penetration of the mesoappendix does not seem to be as important a prognostic factor as the size of the primary tumor and is not separately categorized.
TXPrimary tumor cannot be assessed.
T0No evidence of primary tumor.
T1Tumor ≤2 cm in greatest dimension.
T1aTumor ≤1 cm in greatest dimension.
T1bTumor >1 cm but not >2 cm.
T2Tumor >2cm but not >4 cm or with extension to the cecum.
T3Tumor >4 cm or with extension to the ileum.
T4Tumor directly invades other adjacent organs or structures, e.g., abdominal wall and skeletal muscle.c
1|2|3

WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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