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Cellular Classification of Extrahepatic Bile Duct Cancer

    The term, cholangiocarcinoma, is sometimes used to refer to any primary cancer of the biliary system; however, its use is often restricted to intrahepatic tumors and, therefore, it is not included in this summary. Adenocarcinomas are the most common type of extrahepatic bile duct cancers. The histologic types are listed below:[1,2]

    • Carcinomain situ.
    • Adenocarcinoma, not otherwise specified (NOS).
    • Adenocarcinoma, intestinal type.
    • Mucinous adenocarcinoma.
    • Clear cell adenocarcinoma.
    • Signet-ring cell carcinoma.
    • Adenosquamous carcinoma.
    • Squamous cell carcinoma.
    • Small cell (oat cell) carcinoma.
    • Undifferentiated carcinoma.
      • Spindle and giant cell types.
      • Small cell types.
    • Papillomatosis.
    • Papillary carcinoma, noninvasive.
    • Papillary carcinoma, invasive.
    • Carcinoma, NOS.

    Malignant mesenchymal tumors, although rare, include the following:

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    1. Perihilar bile ducts. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 219-22.
    2. Distal bile duct. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 227-33.

      WebMD Public Information from the National Cancer Institute

      Last Updated: February 25, 2014
      This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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