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Extrahepatic Bile Duct Cancer Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Cellular Classification of Extrahepatic Bile Duct Cancer

The term, cholangiocarcinoma, is sometimes used to refer to any primary cancer of the biliary system; however, its use is often restricted to intrahepatic tumors and, therefore, it is not included in this summary. Adenocarcinomas are the most common type of extrahepatic bile duct cancers. The histologic types are listed below:[1,2]

  • Carcinomain situ.
  • Adenocarcinoma, not otherwise specified (NOS).
  • Adenocarcinoma, intestinal type.
  • Mucinous adenocarcinoma.
  • Clear cell adenocarcinoma.
  • Signet-ring cell carcinoma.
  • Adenosquamous carcinoma.
  • Squamous cell carcinoma.
  • Small cell (oat cell) carcinoma.
  • Undifferentiated carcinoma.
    • Spindle and giant cell types.
    • Small cell types.
  • Papillomatosis.
  • Papillary carcinoma, noninvasive.
  • Papillary carcinoma, invasive.
  • Carcinoma, NOS.

Malignant mesenchymal tumors, although rare, include the following:

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Human / Clinical Studies

The anticancer efficacy of the Gonzalez regimen has been investigated in two human studies ( CPMC-IRB-8544 [1]), both involving patients with pancreatic cancer. The first study, a prospective nonconsecutive case series conducted by the developer and an associate, included 11 patients diagnosed with adenocarcinoma of the pancreas (stage II through stage IV). None of the patients had received chemotherapy or radiation therapy, and none had undergone surgical resection with curative intent. All the...

Read the Human / Clinical Studies article > >

References:

  1. Perihilar bile ducts. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 219-22.
  2. Distal bile duct. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 227-33.
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WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
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