Cartilage (Bovine and Shark) (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Overview
This complementary and alternative medicine (CAM) information summary provides an overview of the use of cartilage as a treatment for people with cancer. The summary includes a brief history of cartilage research, the results of clinical studies, and possible side effects of cartilage use.
This summary contains the following key information:
Note: Some citations in the text of this section are followed by a level of evidence. The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.)
Incidence and Mortality
Note: Estimated new cases and deaths from testicular cancer in the United States in 2012:
New cases: 8,590.
Bovine (cow) cartilage and shark cartilage have been studied as treatments for people with cancer and other medical conditions for more than 30 years.
Numerous cartilage products are sold commercially in the United States as dietary supplements.
Three principal mechanisms of action have been proposed to explain the antitumor potential of cartilage: (1) it kills cancer cells directly; (2) it stimulates the immune system; and (3) it blocks the formation of new blood vessels (angiogenesis), which tumors need for unrestricted growth.
At least three different inhibitors of angiogenesis have been identified in bovine cartilage, and two angiogenesis inhibitors have been purified from shark cartilage.
Few human studies of cartilage as a treatment for people with cancer have been reported to date, and the results are inconclusive.
Additional clinical trials of cartilage as a treatment for people with cancer are now being conducted.
Many of the medical and scientific terms used in this summary are hypertext linked (at first use in each section) to the NCI Dictionary of Cancer Terms, which is oriented toward nonexperts. When a linked term is clicked, a definition will appear in a separate window.
Reference citations in some PDQ CAM information summaries may include links to external Web sites that are operated by individuals or organizations for the purpose of marketing or advocating the use of specific treatments or products. These reference citations are included for informational purposes only. Their inclusion should not be viewed as an endorsement of the content of the Web sites, or of any treatment or product, by the PDQ Cancer CAM Editorial Board or the National Cancer Institute.
WebMD Public Information from the National Cancer Institute
September 04, 2014
This information is not intended to replace the advice of a doctor.
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