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Hydrazine Sulfate (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Human / Clinical Studies

Studies of Hydrazine Sulfate in Which Therapeutic Benefit Was Assesseda

Reference Citation(s)Type of StudyType of CancerNo. of Patients: Enrolled; Treated; ControlbStrongest Benefit ReportedcConcurrent TherapydLevel of Evidence Scoree
No. = number.
a See text for more details.
b Number of patients treated plus number of control patients may not equal number of patients enrolled; number of patients enrolled = number of patients initially recruited/considered by the researchers who conducted a study; number of patients treated = number of enrolled patients who were given the treatment being studiedAND for whom results were reported; historical control subjects are not included in number of patients enrolled.
c The strongest evidence reported that the treatment under study has anticancer activity or otherwise improves the well-being of cancer patients. See text and glossary for definition of terms.
d Surgery, chemotherapy, or radiation therapy given/allowed at the same time as hydrazine sulfate treatment.
e For information about levels of evidence analysis and an explanation of the level of evidence scores, seeLevels of Evidence for Human Studies of Cancer Complementary and Alternative Medicine.
f This study included six additional patients with benign brain tumors.
g Insufficient information given to permit a level of evidence analysis.
[1]Randomized clinical trialAdvanced nonsmall cell lung65; 32; 33, placeboNoneYes1iA
[4,15]Randomized clinical trialAdvanced nonsmall cell lung291; 135; 131, placeboNoneYes1iA
[5]Randomized clinical trialAdvanced colorectal128; 63; 64, placeboNoneNo1iA
[6]Randomized clinical trialAdvanced nonsmall cell lung243; 119; 118, placeboNoneYes1iA
[2]Nonconsecutive case seriesVarious advanced25; 25; NoneSlight regression of some metastatic lesions, 1 patient with melanomaNo3iiiDiii
[3]Nonconsecutive case seriesVarious advanced158; 84; NoneMeasurable tumor regression, 7 patientsYes3iiiDiii
[7,9,10]Nonconsecutive case seriesVarious advanced763; 740; NoneComplete tumor regression, 6 patientsNo3iiiDiii
[8]Nonconsecutive case seriesVarious advanced25; 25; NoneNoneNo3iiiDiii
[11]Nonconsecutive case seriesVarious advanced32; 29; NoneNoneUnknown3iiiDiii
[12]Nonconsecutive case seriesVarious advanced101; 71; 30, placeboImproved weight maintenance or gain, 41 hydrazine sulfate treated vs. 17 placebo-treated patientsYes3iiiDiii
[18]Nonconsecutive case seriesGlioblastoma, astrocytoma, or meningiomaf465; 46; NoneImproved survival, patients with glioblastomaYesNoneg

References:

  1. Chlebowski RT, Bulcavage L, Grosvenor M, et al.: Hydrazine sulfate influence on nutritional status and survival in non-small-cell lung cancer. J Clin Oncol 8 (1): 9-15, 1990.
  2. Spremulli E, Wampler GL, Regelson W: Clinical study of hydrazine sulfate in advanced cancer patients. Cancer Chemother Pharmacol 3 (2): 121-4, 1979.
  3. Gold J: Use of hydrazine sulfate in terminal and preterminal cancer patients: results of investigational new drug (IND) study in 84 evaluable patients. Oncology 32 (1): 1-10, 1975.
  4. Kosty MP, Fleishman SB, Herndon JE 2nd, et al.: Cisplatin, vinblastine, and hydrazine sulfate in advanced, non-small-cell lung cancer: a randomized placebo-controlled, double-blind phase III study of the Cancer and Leukemia Group B. J Clin Oncol 12 (6): 1113-20, 1994.
  5. Loprinzi CL, Kuross SA, O'Fallon JR, et al.: Randomized placebo-controlled evaluation of hydrazine sulfate in patients with advanced colorectal cancer. J Clin Oncol 12 (6): 1121-5, 1994.
  6. Loprinzi CL, Goldberg RM, Su JQ, et al.: Placebo-controlled trial of hydrazine sulfate in patients with newly diagnosed non-small-cell lung cancer. J Clin Oncol 12 (6): 1126-9, 1994.
  7. Filov VA, Gershanovich ML, Danova LA, et al.: Experience of the treatment with Sehydrin (Hydrazine Sulfate, HS) in the advanced cancer patients. Invest New Drugs 13 (1): 89-97, 1995.
  8. Lerner HJ, Regelson W: Clinical trial of hydrazine sulfate in solid tumors. Cancer Treat Rep 60 (7): 959-60, 1976.
  9. Gershanovich ML, Danova LA, Kondratyev VB, et al.: Clinical data on the antitumor activity of hydrazine sulfate. Cancer Treat Rep 60 (7): 933-5, 1976.
  10. Gershanovich ML, Danova LA, Ivin BA, et al.: Results of clinical study antitumor action of hydrazine sulfate. Nutr Cancer 3 (1): 7-12, 1981.
  11. Ochoa M Jr, Wittes RE, Krakoff IH: Trial of hydrazine sulfate (NSC-150014) in patients with cancer. Cancer Chemother Rep 59 (6): 1151-4, 1975 Nov-Dec.
  12. Chlebowski RT, Bulcavage L, Grosvenor M, et al.: Hydrazine sulfate in cancer patients with weight loss. A placebo-controlled clinical experience. Cancer 59 (3): 406-10, 1987.
  13. Chlebowski RT, Heber D, Richardson B, et al.: Influence of hydrazine sulfate on abnormal carbohydrate metabolism in cancer patients with weight loss. Cancer Res 44 (2): 857-61, 1984.
  14. Gold J: Anabolic profiles in late-stage cancer patients responsive to hydrazine sulfate. Nutr Cancer 3 (1): 13-9, 1981.
  15. Herndon JE 2nd, Fleishman S, Kosty MP, et al.: A longitudinal study of quality of life in advanced non-small cell lung cancer: Cancer and Leukemia Group B (CALGB) 8931. Control Clin Trials 18 (4): 286-300, 1997.
  16. Tayek JA, Sutter L, Manglik S, et al.: Altered metabolism and mortality in patients with colon cancer receiving chemotherapy. Am J Med Sci 310 (2): 48-55, 1995.
  17. Tayek JA, Heber D, Chlebowski RT: Effect of hydrazine sulphate on whole-body protein breakdown measured by 14C-lysine metabolism in lung cancer patients. Lancet 2 (8553): 241-4, 1987.
  18. Filov VA, Gershanovich ML, Ivin BA, et al.: [Therapy of primary brain tumors with segidrin] Vopr Onkol 40 (7-12): 332-6, 1994.
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WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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