Cancer Health Center

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In animal studies, NDV infection has been accomplished by intratumoral,[9,10,12,23,28] Reviewed in [36]intraperitoneal,[23,28,78] Reviewed in [36]intravenous,[36]intramuscular,[43] or subcutaneous[43] injection. NDV-infected, whole cell vaccines have been given to animals by intraperitoneal,[46]intradermal,[47] Reviewed in [36] or subcutaneous injection, Reviewed in [36] or by a combination of subcutaneous and intramuscular injection.[43,79]

In human studies, NDV oncolysates have been administered by subcutaneous [11,42,45,60,63,65,67,68,69,70] or intradermal [62,64] injection. NDV-infected, whole cell vaccines have been administered by intradermal injection only.[49,50,52,53,54,55,56,57,58,71,72,73] In cases where patients have been infected with a lytic strain of NDV, intratumoral,[20] intravenous,[1,59,66,80] or intramuscular [61] injection has been used, as have inhalation[1,6] and direct injection into the colon (i.e., via a colostomy opening).[1] In some instances, cytokine treatment has been combined with NDV therapy.[45,52,53,56,62,64,65,70]

Table 1. Strains of NDV Tested in Human/Clinical Cancer Studiesa

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