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Table 4. Studies of Cancer Treatment by Infection of Patients With NDVa

Reference Citation(s)Type of StudyNDV StrainType of CancerNo. of Patients: Enrolled; Treated; ControlbStrongest Benefit ReportedcConcurrent TherapydLevel of Evidence Scoree
mo = month; No. = number.
a See text and theNCI Dictionary of Cancer Termsfor additional information and definition of terms.
b Number of patients treated plus number of patients control may not equal number of patients enrolled; number of patients enrolled = number of patients initially recruited/considered by the researchers who conducted a study; number of patients treated = number of patients who were given the treatment being studiedAND for whom results were reported; historical control subjects are not included in number of patients enrolled.
c The strongest evidence reported that the treatment under study has anticancer activity or otherwise improves the well being of cancer patients.
d Chemotherapy, radiation therapy, hormonal therapy, or cytokine therapy given/allowed at the same time as virus treatment.
e For information about levels of evidence analysis and an explanation of the level of evidence scores, seeLevels of Evidence for Human Studies of Cancer Complementary and Alternative Medicine.
f This patient was treated with chemotherapy and five other types of virus in addition to NDV.
[39]Phase II trialMTH-68Various advanced59; 33; 26, placeboImproved overall survivalNo2A
[44]Phase I trialPV701Various advanced79; 79; NonePartial tumor regression, 8 patientsUnknown3iiiDiii
[46]Phase I/IIHUJGlioblastoma multiforme, recurrent14 (phase I–6; phase II–8); 11 (phase I–6, phase II–5); 01 transient (3 mo) complete response, all other patients had progressive diseaseNone3iiiDiii
[38]Case seriesMTH-68Various advanced4; 4; NoneComplete tumor regression, 2 patientsYes4
[47]Selected case seriesMTH-68/HGliomas, high-grade4; 4; 0Radiographically documented responses and long survival with improved symptomatologyVarious4Diii
[45]Phase IPV701Various16; 16; 0Improved patient tolerability with two-step desensitizationNoneN/A
[48]Case reportMTH-68/HAnaplastic astrocytoma1; 1; 0Partial responseValproic acidN/A
[40]Case report73-TAdvanced cervical1; 1; NonePartial tumor regressionNoNone
[41]Anecdotal reportMTH-68Various metastatic3; 3; NoneTumor regressionUnknownNone
[42]Case reportMTH-68Glioblastoma multiforme1; 1; NonePartial tumor regressionYesNone
[43]Case reportHickmanAcute myeloid leukemia1; 1; NonePartial responseYesfNone

Current Clinical Trials

Check NCI's list of cancer clinical trials for cancer CAM clinical trials on oncolytic Newcastle disease virus that are actively enrolling patients.

General information about clinical trials is also available from the NCI Web site.

References:

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Last Updated: February 25, 2014
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