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Treatment Options for Childhood Acute Myeloid Leukemia, Myelodysplastic Syndromes, and Juvenile Myelomonocytic Leukemia

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    Recurrent Childhood Acute Myeloid Leukemia

    Treatment of recurrent childhood acute myeloid leukemia may include the following:

    • Combination chemotherapy.
    • Combination chemotherapy and stem cell transplant.
    • A second stem cell transplant.
    • A clinical trial of combinations of new anticancer drugs, new biologic agents, and stem cell transplant using different sources of stem cells.

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent childhood acute myeloid leukemia. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

    Acute Promyelocytic Leukemia

    Treatment of acute promyelocytic leukemia may include the following:

    • All-trans retinoic acid (ATRA) plus chemotherapy.
    • Arsenic trioxide therapy
    • Central nervous system sanctuary therapy with intrathecal chemotherapy.
    • A clinical trial of arsenic trioxide therapy and all-trans retinoic acid plus low-dose chemotherapy.

    Supportive care treatments are used to manage problems caused by the disease, such as infection, bleeding, and anemia.

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with childhood acute promyelocytic leukemia (M3). For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

    Recurrent Acute Promyelocytic Leukemia

    Treatment of recurrent acute promyelocytic leukemia may include the following:

    • All-trans retinoic acid therapy (ATRA) plus chemotherapy.
    • Arsenic trioxide therapy.
    • Targeted therapy with a monoclonal antibody.
    • Stem cell transplant.

    Children with Down Syndrome and AML

    Treatment of acute myeloid leukemia in children who have Down syndrome may include combination chemotherapy plus central nervous system sanctuary therapy with intrathecal chemotherapy.

    Childhood Chronic Myelogenous Leukemia

    Treatment for childhood chronic myelogenous leukemia may include the following:

    • Targeted therapy with Gleevec.
    • Stem cell transplant or other tyrosine kinase inhibitors for patients who do not respond to therapy with Gleevec or whose disease comes back after treatment.
    • A clinical trial of targeted therapy with other tyrosine kinase inhibitors.
    • A clinical trial of stem cell transplant using lower doses of chemotherapy.
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