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Childhood Soft Tissue Sarcoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Childhood Soft Tissue Sarcoma

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Nonmetastatic Childhood Soft Tissue Sarcoma

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For treatment of hemangiopericytoma (in infants and young children) and infantile fibrosarcoma

If an infant or young child has fibrosarcoma or hemangiopericytoma, treatment will be surgery whenever possible. Other treatments may include chemotherapy to reduce the size of the tumor, followed by surgery.

If an older child or adolescent has fibrosarcoma or hemangiopericytoma, treatment will be surgery whenever possible. Other treatments may include the following:

  • Chemotherapy followed by radiation therapy, surgery, or both.
  • Radiation therapy or chemotherapy after surgery.
  • A clinical trial of internal radiation therapy.
  • A clinical trial of radiation therapy given during surgery.

For treatment of desmoid tumor

Treatment of desmoid tumor will be surgery whenever possible. Other treatments may include watchful waiting, chemotherapy, or surgery followed by internal radiation therapy.

If surgery to completely remove the tumor is not possible, treatment to shrink the tumor before surgery may include the following:

  • External radiation therapy
  • A nonsteroidal anti-inflammatory drug (NSAID).
  • Antiestrogen therapy.
  • Chemotherapy.

For treatment of alveolar soft part sarcoma

Treatment of alveolar soft part sarcoma will be surgery whenever possible. Other treatments may include the following:

  • Radiation therapy.
  • A clinical trial of targeted therapy.

For treatment of clear cell sarcoma

Treatment of clear cell sarcoma will be surgery whenever possible. Radiation therapy may be given after surgery.

For treatment of desmoplastic small round cell tumor

Treatment of desmoplastic small round cell tumor may include surgery, chemotherapy (which may be given before surgery), and radiation therapy.

For treatment of extraosseous osteosarcoma

See the PDQ summary on Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment for more information on the treatment of extraosseous osteosarcoma.

For treatment of malignant peripheral nerve sheath tumor

Treatment of malignant peripheral nerve sheath tumor will be surgery whenever possible. Radiation therapy may be given after surgery.

For treatment of plexiform histiocytic tumor

Treatment of plexiform histiocytic tumor is surgery to completely remove the tumor.

For treatment of synovial sarcoma

Treatment of synovial sarcoma may include the following:

  • Surgery with or without chemotherapy.
  • Chemotherapy.

For treatment of undifferentiated soft tissue sarcoma

There is no standard treatment for undifferentiated soft tissue sarcoma. Treatment may be within a clinical trial for patients with nonrhabdomyosarcomatous soft tissue sarcomas (NRSTS).

For treatment of angiosarcoma and lymphangiosarcoma

Treatment of angiosarcoma and lymphangiosarcoma may include the following:

  • Surgery to completely remove the tumor.
  • Radiation therapy or chemotherapy after surgery.

For treatment of hemangioendothelioma

Treatment of hemangioendothelioma in children younger than one year may include the following:

  • Watchful waiting as some tumors will disappear without treatment.
  • Treatment for blood clotting disorders.
  • Surgery to remove the tumor if there are symptoms.
  • Liver transplant (if the tumor is in the liver).
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WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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