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Gastrointestinal Stromal Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Gastrointestinal Stromal Tumors

A formal staging system for gastrointestinal stromal tumors (GIST) appeared for the first time in the 7th edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual.[1] Because of the limited availability of mutation testing, mutation status is not included in the AJCC system. In addition, since nodal involvement is so rare, and nodal dissection is not indicated, the designation N0/pN0 should be used in the absence of information about the regional nodes. Note that treatment decisions may not be based strictly on the stage of disease.[2,3,4]

Definitions of TNM (for GIST at All Sites)

This staging system for GIST is new for the 7th edition of the AJCC Cancer Staging Manual.[1]

Table 2. Primary Tumor (T)a

a Reprinted with permission from AJCC: Gastrointestinal stromal tumor. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
TXPrimary tumor cannot be assessed.
T0No evidence for primary tumor.
T1Tumor ≤2 cm.
T2Tumor >2 cm but not >5 cm.
T3Tumor >5 cm but not >10 cm.
T4Tumor >10 cm in greatest dimension.

Table 3. Regional Lymph Nodes (N)a

a Reprinted with permission from AJCC: Gastrointestinal stromal tumor. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
NXRegional lymph nodes cannot be assessed.
N0No regional lymph node metastasis.
N1Regional lymph node metastasis.

Table 4. Distant Metastasis (M)a

a Reprinted with permission from AJCC: Gastrointestinal stromal tumor. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
M0No distant metastasis.
M1Distant metastasis.
1|2

WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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