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    Neuroblastoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Neuroblastoma

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    Patients First Treated for High-Risk Neuroblastoma

    Treatment for recurrent neuroblastoma may include the following:

    • Combination chemotherapy.
    • mIBG therapy to relieve symptoms and improve quality of life. It may be given alone or in combination with other therapy, or after stem cell rescue.
    • A second course of high-dose chemotherapy and stem cell rescue.

    Because there is no standard treatment for recurrent neuroblastoma in patients first treated for high-risk neuroblastoma, patients may want to consider a clinical trial. For information about clinical trials, please see the NCI Web site.

    Patients with Recurrent CNS Neuroblastoma

    Treatment for neuroblastoma that recurs (comes back) in the central nervous system (CNS; brain and spinal cord) may include the following:

    • Surgery to remove the tumor in the CNS followed by radiation therapy.
    • A clinical trial of a new therapy.

    Treatments in Clinical Trials for Progressive/Recurrent Neuroblastoma

    Some of the treatments being studied in clinical trials for neuroblastoma that recurs (comes back) or progresses (grows, spreads, or does not respond to treatment) include the following:

    • Combination chemotherapy and ch14.18 monoclonal antibody therapy.
    • Lenalidomide and ch14.18 monoclonal antibody therapy with or without isotretinoin.
    • Vaccine therapy.
    • A tyrosine kinase inhibitor (crizotinib) with or without combination chemotherapy.

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with neuroblastoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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