Skip to content

    Cancer Health Center

    Font Size

    Newcastle Disease Virus (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Human / Clinical Studies

    Table 3. Studies of NDV-Infected Tumor Cell Vaccines in Which Therapeutic Benefit Was Assesseda

    Reference Citation(s) Type of Study Type of Cancer No. of Patients: Enrolled; Treated; Controlb Strongest Benefit Reportedc Concurrent Therapyd Level of Evidence Scoree
    No. = number; wk = week.
    a Refer to text and theNCI Dictionary of Cancer Termsfor additional information and definition of terms.
    b Number of patients treated plus number of patients control may not equal number of patients enrolled; number of patients enrolled = number of patients initially recruited/considered by the researchers who conducted a study; number of patients treated = number of enrolled patients who were given the treatment being studiedAND for whom results were reported; historical control subjects are not included in number of patients enrolled.
    c The strongest evidence reported that the treatment under study has anticancer activity or otherwise improves the well-being of cancer patients.
    d Chemotherapy, radiation therapy, hormonal therapy, or cytokine therapy given/allowed at the same time as vaccine therapy.
    e For information about levels of evidence analysis and an explanation of the level of evidence scores, refer toLevels of Evidence for Human Studies of Cancer Complementary and Alternative Medicine.
    f Only 48 patients were treated with NDV-infected tumor cell vaccines; the remaining patients were treated with another type of vaccine.
    g The patients were divided into groups that received a high-quality vaccine or a low-quality vaccine; the low-quality vaccine groups served as the controls; 32, 13, and 18 patients with early breast cancer, metastatic breast cancer, and metastatic ovarian cancer, respectively, received high-quality vaccines; the corresponding low-quality vaccine groups contained 31,14, and 13 patients.
    h There were 39 evaluable patients in this study, but findings were reported for only 24 patients.
    i Article does not provide enough information.
    [32] Phase II/III (adjuvant setting) Melanoma 29; 21; 8 No advantage of vaccine for disease free survival or overall survival None 1iA
    [29] Phase III (adjuvant setting) Colorectal with liver metastases 51; 25; 26 Planned subgroup analysis, overall and disease free survival advantages in the colon of cancer patients Protocol therapy was given after complete surgical resection of primary tumor and liver metastases 1iiA
    [31] Phase II Glioblastoma 35; 23; 87 (concurrent controls identified from within same hospital) Median progression-free survival of vaccinated patients was 40 wk (vs. 26 wk in controls; log-rank test,P = .024), median OS of vaccinated patients was 100 wk (vs. 49 wk in controls; log-rank test,P< .001) Protocol therapy after surgical debulking of tumor followed by radiation therapy 2A
    [15,22] Phase II trial Metastatic colorectal 23; 23; Historical controls Improved disease-free survival No 3iiA
    [23] Phase II trial Ovarian 82; 24h; None Improved disease-free survival Yes 3iiDi
    [16] Phase II trial Advanced colorectal 57; 48f; Historical controls Improved overall survival No 3iiiA
    [17] Retrospective analysis Early breast 63; 63; Internal controlsg Improved overall survival Yes 3iiiA
    [21] Phase II trial Metastatic renal cell 40; 40; Historical controls Improved overall survival, 11 patients with complete/partial responses Yes 3iiiA
    [19] Phase II trial Various advanced 43; 31; None Complete tumor response, 1 patient Yes 3iiiDiii
    [33] Phase II Gastrointestinal tumors, stage IV 25; 25; 0 1 Complete response, 5 partial responses, overall response rate = 24% None described 3iiiDiii
    [33] Phase III Colorectal 567; 310; 257 Higher mean and median survival for vaccination group compared to the resection group alone None described None describedi
    1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16
    1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16
    Next Article:

    Today on WebMD

    man holding lung xray
    What you need to know.
    stem cells
    How they work for blood cancers.
    woman wearing pink ribbon
    Separate fact from fiction.
    Colorectal cancer cells
    Symptoms, screening tests, and more.
    Jennifer Goodman Linn self-portrait
    what is your cancer risk
    colorectal cancer treatment advances
    breast cancer overview slideshow
    prostate cancer overview
    lung cancer overview slideshow
    ovarian cancer overview slideshow
    Actor Michael Douglas