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Cancer Health Center

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Newcastle Disease Virus (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Human / Clinical Studies

Table 2. Studies of NDV Oncolysates in Which Therapeutic Benefit Was Assesseda,b

Reference Citation(s) Type of Study Type of Cancer No. of Patients: Enrolled; Treated; Controlc Strongest Benefit Reportedd Concurrent Therapye Level of Evidence Scoref
No. = number.
a Refer to text and theNCI Dictionary of Cancer Termsfor additional information and definition of terms.
b Oncolysates are prepared from virus-infected cancer cells; they consist primarily of cellmembranefragments and contain virusproteinsand cancer cell proteins.
c Number of patients treated plus number of patients control may not equal number of patients enrolled; number of patients enrolled = number of patients initially recruited/considered by the researchers who conducted a study; number of patients treated = number of enrolled patients who were given the treatment being studiedAND for whom results were reported; historical control subjects are not included in number of patients enrolled.
d The strongest evidence reported that the treatment under study has anticancer activity or otherwise improves the well-being of cancer patients.
e Chemotherapy, radiation therapy,hormonal therapy, or cytokine therapy given/allowed at the same time as oncolysate treatment.
f For information about levels of evidence analysis and an explanation of the level of evidence scores, refer toLevels of Evidence for Human Studies of Cancer Complementary and Alternative Medicine.
[1,2,4,11] Phase II trial Advanced melanoma 32; 32; Historical controls Improved overall survival No 3iiA
[1,2,11] Phase II trial Advanced melanoma 51; 51; Historical controls Improved overall survival No 3iiA
[6] Phase II trial Advanced melanoma 24; 24; Historical controls None No 3iiDi
[5,7] Phase II trial Metastatic breast or ovarian 22; 22; None Complete/partial tumor response, 9 patients Yes 3iiDiii
[8,12] Phase II trial Advanced renal cell 208; 203; Historical controls Improved disease-free survival Yes 3iiiDi
[9,10] Phase I trial Advanced melanoma 13; 13; None Complete tumor response, 1 patient Yes 3iiiDii

Immunotherapy With Whole Cell Vaccines

The following information is summarized in a table located at the end of this section.

Most clinical studies of NDV-infected, whole cell vaccines that have been reported in scientific literature were conducted in Germany.[15,16,17,18,19,20,21,22,23,24,25,26,27,31,32] However, the largest reported trial was performed in China.[14,33,34,35,36] Most of these studies involved patients with colorectal cancer,[15,16,19,20,22,33] breast cancer,[17,18,25] ovarian cancer,[17,18,23] renal cell cancer,[21,26] or malignant glioma.[31] The nonlytic strain NDV Ulster was used to prepare autologous tumor cell vaccines in all of the studies.

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