Skip to content

    Cancer Health Center

    Font Size

    Newcastle Disease Virus (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Laboratory / Animal / Preclinical Studies

    Effects of Newcastle Disease Virus on Human Cancer Cells

    The ability of Newcastle disease virus (NDV) to replicate efficiently in human cancer cells has been demonstrated in both laboratory studies and animal studies.[1,2,3,4,5,6,7,8,9,10,11,12,13,14] Further, several of these studies suggest that lytic strains of NDV are also oncolytic, and one study has demonstrated that expression of the RAC1 gene is necessary for NDV replication.[15]

    Recommended Related to Cancer

    General Information About Testicular Cancer

    Incidence and Mortality Estimated new cases and deaths from testicular cancer in the United States in 2014:[1] New cases: 8,820. Deaths: 380. Testicular cancer is a highly treatable, usually curable, cancer that most often develops in young and middle-aged men. Most testicular cancers are germ cell tumors. For treatment planning, germ cell tumors are broadly divided into seminomas and nonseminomas because they have different prognostic and treatment algorithms. For patients with...

    Read the General Information About Testicular Cancer article > >

    Lytic strain 73-T has been shown to replicate efficiently in human tumor cells [16] and kill the following types of human cancer cells in vitro: fibrosarcoma, osteosarcoma, neuroblastoma, bladder carcinoma, cervical carcinoma, melanoma, Wilms tumor, and myeloid leukemia;[3,6,8,9]. It killed normal human lung fibroblasts in vitro at the same rate that it killed cancer cells.[8] However, this strain did not kill human B-cell lymphoma (i.e., Burkitt lymphoma) cells in vitro[8] and did not kill normal, proliferating human white blood cells or normal human skin fibroblasts in vitro.[3,6,8]

    Lytic strain Roakin has been reported to kill human lymphoma B cells and T cells transformed in vitro from a Hodgkin lymphoma patient four to five times faster than it killed normal, resting human white blood cells.[4,5] This strain killed normal, proliferating human white blood cells in vitro, although at a lower rate than in cancer cells.[4]

    Lytic strain Italien (or Italian) has been shown to kill human squamous cell lung carcinoma, melanoma, breast carcinoma, and larynx carcinoma, but not cervical carcinoma, cells in vitro.[12]

    Overall, these results suggest that the lytic strains of NDV replicate well in some types of normal cells and replicate poorly in some types of cancer cells. These data and the absence of serious illness in individuals infected with NDV [1,2,3,10,13,17,18,19,20,21,22]) are consistent with the view that NDV may replicate more efficiently in human cancer cells than it does in most types of normal human cells (i.e., "DBTRG.05MG human glioblastoma," "U-87MG human astrocytoma,"[23] "rat F98 glioblastoma cells,"[24] and "mouse Ehrlich ascites carcinoma").[25]

    1 | 2 | 3 | 4 | 5
    1 | 2 | 3 | 4 | 5
    Next Article:

    Today on WebMD

    Colorectal cancer cells
    New! I AM Not Cancer Facebook Group
    Lung cancer xray
    See it in pictures, plus read the facts.
    sauteed cherry tomatoes
    Fight cancer one plate at a time.
    Ovarian cancer illustration
    Real Cancer Perspectives
    Jennifer Goodman Linn self-portrait
    what is your cancer risk
    colorectal cancer treatment advances
    breast cancer overview slideshow
    prostate cancer overview
    lung cancer overview slideshow
    ovarian cancer overview slideshow
    Actor Michael Douglas